The influence of selenium on immune responses.

The influence of selenium on immune responses.
复制标题

硒对免疫反应的影响。

DOI:
10.1002/mnfr.200700330
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发表时间:
2008-11
影响因子:
5.2
通讯作者:
Berry, Marla J.
Berry, Marla J.
中科院分区:
农林科学2区
文献类型:
--
作者:
Hoffmann, Peter R.;Berry, Marla J.

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硒(Se)是一种有效的营养抗氧化剂,它通过掺入硒蛋白来发挥生物学效应。鉴于硒蛋白在几乎所有组织中对调节活性氧(ROS)和氧化还原状态都起着至关重要的作用,饮食中的硒对炎症和免疫反应有强烈影响也就不足为奇了。硒“增强”免疫系统的观点得到了涉及衰老免疫或针对某些病原体的保护的研究的支持。然而,研究硒状态对其他类型免疫(如抗寄生虫反应或过敏性哮喘)的影响的实验表明,更多的硒并不总是有益的。在这篇综述中,我们总结并比较了有关硒水平如何影响不同类型免疫的现有数据。总体而言,确定硒摄入量如何对不同类型的免疫反应产生差异影响以及剖析这种影响发生的机制,将有助于更好地利用硒补充剂来治疗涉及免疫系统的人类疾病。
Selenium (Se) is a potent nutritional antioxidant that carries out biological effects through its incorporation into selenoproteins. Given the crucial roles that selenoproteins play in regulating reactive oxygen species (ROS) and redox status in nearly all tissues, it is not surprising that dietary Se strongly influences inflammation and immune responses. The notion that Se “boosts” the immune system has been supported by studies involving aging immunity or protection against certain pathogens. However, studies examining the effects of Se status on other types of immunity such as antiparasitic responses or allergic asthma have suggested more Se may not always be beneficial. In this review, we summarize and compare the available data regarding how the levels of Se affect different types of immunity. Overall, determining how Se intake differentially affects various types of immune responses and dissecting the mechanisms by which this occurs will lead to a better utilization of Se-supplementation for human diseases involving the immune system.
DOI: 10.1093/jn/116.5.816
发表时间: 1986-05-01
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