Mesenchymal stem cells and tooth engineering.

Mesenchymal stem cells and tooth engineering.
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间充质干细胞和牙齿工程

DOI:
10.4248/ijos.08032
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发表时间:
2009-03
影响因子:
14.9
通讯作者:
Zhou XD
Zhou XD
中科院分区:
医学1区
文献类型:
--
作者:
Peng L;Ye L;Zhou XD

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牙齿脱落危害人类口腔健康。虽然一些修复方法,如人工义齿和牙科植入物,是牙齿脱落问题的临床治疗方法,但它们被认为存在安全性和使用时间问题。近年来,牙组织工程受到越来越多的关注。基于干细胞的组织工程被认为是一种很有前途的方法来取代缺失的牙齿。间充质干细胞(Mesenchymal stem cells,MSCs)是一种具有多向分化潜能的干细胞。具有牙齿再生潜力的间充质干细胞主要包括人脱落乳牙干细胞(SHED)、成人牙髓干细胞(DPSC)、牙乳头根尖部干细胞(SCAPs)、牙囊干细胞(DFSC)、牙周膜干细胞(PDLSC)和骨髓间充质干细胞(BMSCs)。本文就近年来间充质干细胞在牙齿再生中的应用作一综述。
Tooth loss compromises human oral health. Although several prosthetic methods, such as artificial denture and dental implants, are clinical therapies to tooth loss problems, they are thought to have safety and usage time issues. Recently, tooth tissue engineering has attracted more and more attention. Stem cell based tissue engineering is thought to be a promising way to replace the missing tooth. Mesenchymal stem cells (MSCs) are multipotent stem cells which can differentiate into a variety of cell types. The potential MSCs for tooth regeneration mainly include stem cells from human exfoliated deciduous teeth (SHEDs), adult dental pulp stem cells (DPSCs), stem cells from the apical part of the papilla (SCAPs), stem cells from the dental follicle (DFSCs), periodontal ligament stem cells (PDLSCs) and bone marrow derived mesenchymal stem cells (BMSCs). This review outlines the recent progress in the mesenchymal stem cells used in tooth regeneration.
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