New neurons generated from running are broadly recruited into neuronal activation associated with three different hippocampus-involved tasks.
New neurons generated from running are broadly recruited into neuronal activation associated with three different hippocampus-involved tasks.
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DOI：
10.1002/hipo.22020
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发表时间：
2012-09
期刊：
影响因子：
3.5
通讯作者：
Rhodes, Justin S.
中科院分区：
文献类型：
--
作者：
Clark, Peter J.;Bhattacharya, Tushar K.;Miller, Daniel S.;Kohman, Rachel A.;DeYoung, Erin K.;Rhodes, Justin S.
跑步增加了成年啮齿动物海马中新神经元的形成。然而，跑步产生的新神经元的功能目前尚不清楚。一种假设是，跑步产生的新神经元通过增加成人海马体的可塑性，有助于增强认知功能。另一种假设是，跑步产生的新神经元与只在跑步时活跃的体验特异性海马网络相结合。这项实验的目的是确定跑步产生的新神经元是被跑步选择性地激活，还是被招募到与海马有关的其他行为任务中发生的颗粒细胞活动中。因此，使用BrdU、NeuN和Zif268三标签免疫组织化学检测了雌性跑步和久坐的成年C57BL/6J小鼠在参与莫里斯水迷宫、新环境探索或轮式跑步三种不同任务之一后，新5-6周神经元的激活情况。结果显示，跑步和久坐的小鼠在每项任务后都显示出几乎相同比例的新神经元表达Zif268。由于跑步大约使新神经元的数量增加了一倍，结果表明，跑步小鼠在每次任务后的颗粒细胞层中有更多的新神经元招募到Zif268诱导中，而不是久坐的小鼠。结果表明，跑步后并入海马体回路的新神经元不仅被跑步本身激活，而且在不同的行为体验中被广泛招募到颗粒细胞层活动中。
Running increases the formation of new neurons in the adult rodent hippocampus. However, the function of new neurons generated from running is currently unknown. One hypothesis is that new neurons from running contribute to enhanced cognitive function by increasing plasticity in the adult hippocampus. An alternative hypothesis is that new neurons generated from running incorporate into experience-specific hippocampal networks that only become active during running. The purpose of this experiment was to determine if new neurons generated from running are selectively activated by running, or can become recruited into granule cell activity occurring during performance on other behavioral tasks that engage the hippocampus. Therefore, the activation of new 5–6 week neurons was detected using BrdU, NeuN, and Zif268 triple-label immunohistochemistry in cohorts of female running and sedentary adult C57BL/6J mice following participation in one of three different tasks: the Morris water maze, novel environment exploration, or wheel running. Results showed that running and sedentary mice displayed a nearly equivalent proportion of new neurons that expressed Zif268 following each task. Since running approximately doubled the number of new neurons, the results demonstrated that running mice had a greater number of new neurons recruited into the Zif268 induction in the granule cell layer following each task than sedentary mice. The results suggest that new neurons incorporated into hippocampal circuitry from running are not just activated by wheel running itself, but rather become broadly recruited into granule cell layer activity during distinct behavioral experiences.
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影响因子：
3.5
作者：
Clark, Peter J.;Brzezinska, Weronika J.;Puchalski, Emily K.;Krone, David A.;Rhodes, Justin S.
通讯作者：
Rhodes, Justin S.
DOI：
10.1073/pnas.0809650106
发表时间：
2009-02-24
影响因子：
11.1
作者：
Dalla, Christina;Papachristos, Efstathios B.;Shors, Tracey J.
通讯作者：
Shors, Tracey J.
影响因子：
3.3
作者：
Redila, VA;Christie, BR
通讯作者：
Christie, BR
影响因子：
2.9
作者：
Neeper, SA;GomezPinilla, F;Cotman, CW
通讯作者：
Cotman, CW
影响因子：
25
作者：
Kee, Nohjin;Teixeira, Catia M.;Frankland, Paul W.
通讯作者：
Frankland, Paul W.