Cognitive control network connectivity in adolescent women with and without a parental history of depression.
Cognitive control network connectivity in adolescent women with and without a parental history of depression.
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DOI：
10.1016/j.dcn.2013.10.008
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发表时间：
2014-01
影响因子：
4.7
通讯作者：
Schnyer, David M.
中科院分区：
文献类型：
--
作者：
Clasen, Peter C.;Beevers, Christopher G.;Mumford, Jeanette A.;Schnyer, David M.
关键词：
父母有抑郁症史的少女患重度抑郁症的风险很高。这种风险可能与情绪信息的认知控制缺陷有关。事实上，这些女孩表现出这种缺陷的行为证据。我们报告说，他们也显示这些赤字的神经证据。具体来说，网络中的连接缺陷与情绪的认知控制有关。父母有抑郁症病史的青少年女性是发生重度抑郁症（MDD）的高危人群。认知理论表明，这种脆弱性涉及对情感信息的认知控制缺陷。在有和没有父母抑郁史的青少年女性中，我们使用静息状态功能连接分析与情绪信息认知控制相关的网络内的连接差异。24例抑郁症初治青少年女性接受静息状态功能磁共振成像（fMRI）。他们被分配到高风险（n = 11）和低风险（n = 13）组的基础上，他们的父母的抑郁症病史。基于种子的功能连接分析被用来检查与认知控制相关的网络内的连接的组差异。高风险青少年的右下前额叶区域与注意力控制网络的其他关键节点（包括右额中回和右缘上回）之间的连接水平较低。此外，父母最严重的抑郁发作的严重程度与青春期女儿的认知控制网络连接的改变有关。抑郁的父母可能会通过改变神经回路内的功能连接将抑郁症易感性传递给他们青春期的女儿，这些神经回路是情绪信息认知控制的基础。
Adolescent girls with a parental history of depression are at high risk for major depression. This risk may be associated with deficits in cognitive control for emotional information. Indeed, these girls show behavioral evidence of such deficits. We report that they also show neural evidence of these deficits. Specifically, connectivity deficits in a network associated with cognitive control of emotion. Adolescent women with a parental history of depression are at high risk for the onset of major depressive disorder (MDD). Cognitive theories suggest this vulnerability involves deficits in cognitive control over emotional information. Among adolescent women with and without a parental history of depression, we examined differences in connectivity using resting state functional connectivity analysis within a network associated with cognitive control over emotional information. Twenty-four depression-naïve adolescent women underwent resting state functional magnetic resonance imaging (fMRI). They were assigned to high-risk (n = 11) and low-risk (n = 13) groups based their parents’ depression history. Seed based functional connectivity analysis was used to examine group differences in connectivity within a network associated with cognitive control. High-risk adolescents had lower levels of connectivity between a right inferior prefrontal region and other critical nodes of the attention control network, including right middle frontal gyrus and right supramarginal gyrus. Further, greater severity of the parents’ worst episode of depression was associated with altered cognitive control network connectivity in their adolescent daughters. Depressed parents may transmit depression vulnerability to their adolescent daughters via alterations in functional connectivity within neural circuits that underlie cognitive control of emotional information.
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DOI：
10.1080/15374410902851705
发表时间：
2009-05
期刊：
Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
影响因子：
--
作者：
Gibb BE;Benas JS;Grassia M;McGeary J
通讯作者：
McGeary J
影响因子：
4.6
作者：
Joormann, Jutta;Talbot, Lisa;Gotlib, Ian H.
通讯作者：
Gotlib, Ian H.
影响因子：
2.9
作者：
De Raedt, Rudi;Koster, Ernst H. W.
通讯作者：
Koster, Ernst H. W.
影响因子：
10.6
作者：
Greicius, Michael D.;Flores, Benjamin H.;Schatzberg, Alan F.
通讯作者：
Schatzberg, Alan F.
影响因子：
4.8
作者：
Hamilton, J. Paul;Glover, Gary H.;Hsu, Jung-Jiin;Johnson, Rebecca F.;Gotlib, Ian H.
通讯作者：
Gotlib, Ian H.