Seasonal variations in cellular and humoral immunity in male striped hamsters (Cricetulus barabensis).
Seasonal variations in cellular and humoral immunity in male striped hamsters (Cricetulus barabensis).
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雄性条纹仓鼠（Cricetulus barabensis）细胞和体液免疫的季节性变化
DOI：
10.1242/bio.038489
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发表时间：
2018-12-10
期刊：
影响因子：
2.4
通讯作者：
Tian Y
中科院分区：
文献类型：
--
作者：
Xu DL;Hu XK;Tian Y
非热带地区的动物通常表现出免疫功能的季节性变化，这对它们的生存至关重要。本研究对条纹仓鼠（Cricetulus barabensis）免疫的季节变化进行了研究，以验证冬季免疫增强假说。2014年秋冬和2015年春夏分别从野外捕获雄性仓鼠。鼠体质量、体脂质量和血糖水平均在夏季最高，而相对脂肪和胸腺质量无季节变化。脾脏肿块在秋季最高，白细胞和植物血凝素（PHA）反应在夏季最低，这支持了冬季免疫增强假说。IgG和IgM滴度在秋季最低，这与这一假设相反。体脂量与细胞和体液免疫没有相关性，这表明它不是男性细胞和体液免疫发生季节性变化的原因。春、夏季瘦素效价高于秋、冬季。瘦素与细胞和体液免疫之间没有相关性，表明瘦素没有调节它们的季节变化。同样，皮质酮水平在春季和夏季也高于秋季和冬季，这与细胞免疫呈负相关，而与IgG水平呈正相关。提示皮质酮对细胞免疫有抑制作用，对体液免疫有增强作用。总之，免疫系统的不同组成部分表现出不同的季节模式。本文以第一人称采访了该论文的第一作者。摘要：条纹仓鼠免疫、体脂、血糖、瘦素和皮质酮的季节性变化及其相关性。
ABSTRACT Animals in the non-tropical zone usually demonstrate seasonal variations in immune function, which is important for their survival. In the present study, seasonal changes in immunity in striped hamsters (Cricetulus barabensis) were investigated to test the winter immunoenhancement hypothesis. Male hamsters were captured from the wild in the fall and winter of 2014 and in the spring and summer of 2015. Body mass, body fat mass and blood glucose levels of the hamsters were all highest in the summer, whereas relative fatness and thymus mass had no seasonal changes. Spleen mass was highest in the fall and white blood cells and phytohaemagglutinin (PHA) response indicative of cellular immunity were lowest in the summer among the four seasons, which supports the winter immunoenhancement hypothesis. IgG and IgM titers were lowest in the fall, which was against this hypothesis. Body fat mass had no correlations with cellular and humoral immunity, suggesting it was not the reason for seasonal changes in cellular and humoral immunity in males. Leptin titers were higher in spring and summer than in fall and winter. No correlation between leptin and cellular and humoral immunity suggested that leptin did not mediate their seasonal changes. Similarly, corticosterone levels were also higher in spring and summer than in fall and winter, which correlated negatively with cellular immunity but positively with IgG levels. This result implied that corticosterone has a suppressive effect on cellular immunity and an enhancing effect on humoral immunity. In summary, distinct components of immune systems exhibited different seasonal patterns. This article has an associated First Person interview with the first author of the paper. Summary: Seasonal changes in immunity, body fat, blood glucose, leptin and corticosterone and their correlations in striped hamsters.
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DOI：
10.1016/j.cbpa.2006.08.045
发表时间：
2006-12-01
影响因子：
2.3
作者：
de Bellocq, Joelle Gouy;Krasnov, Boris R.;Pinshow, Berry
通讯作者：
Pinshow, Berry
影响因子：
2.6
作者：
Fernandez-de-Mera, I. G.;Jaroso, R.;Gortazar, C.
通讯作者：
Gortazar, C.
影响因子：
4.8
作者：
LOCHMILLER, RL;VESTEY, MR;MCMURRY, ST
通讯作者：
MCMURRY, ST
季节性适应的布氏田鼠（Microtus Brandti）的体重和产热调节
影响因子：
3.5
作者：
Li, XS;Wang, DH
通讯作者：
Wang, DH
影响因子：
3.5
作者：
Demas, GE
通讯作者：
Demas, GE