Nature Exposure and Its Effects on Immune System Functioning: A Systematic Review.
Nature Exposure and Its Effects on Immune System Functioning: A Systematic Review.
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DOI：
10.3390/ijerph18041416
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发表时间：
2021-02-03
影响因子：
--
通讯作者：
Stigsdotter UKK
中科院分区：
文献类型：
--
作者：
Andersen L;Corazon SSS;Stigsdotter UKK
鉴于我们的生活方式和全球生态系统发生了巨大变化，自然环境对健康的潜在影响已成为一个非常普遍的话题。最近的科学发现表明，接触大自然对人体免疫反应有有益的影响。本综述旨在对已发表的有关吸入天然物质对自然暴露的免疫调节作用的文献进行全面概述。在 SCOPUS 和 PubMed 中进行了系统的数据库检索。通过应用 EPHPP（有效公共卫生实践项目）工具进行人体研究，应用 ARRIVE（动物研究：体内实验报告）和 SYRCLE（实验动物实验系统审查中心）工具进行动物研究，对纳入研究 (n = 33) 的质量和潜在偏倚进行评估。综合审查的研究表明，接触自然对免疫健康参数有积极影响；例如抗炎、抗过敏、抗哮喘作用或增加 NK（自然杀伤）细胞活性。促炎分子表达减少、白细胞浸润和细胞毒性介质释放等结果可作为进一步研究的基线。然而，部分薄弱的研究设计引起了结果再现性的不确定性，并且关于效应大小、暴露持续时间以及特定植被或生态系统类型的贡献的关键问题仍然悬而未决。
Given the drastic changes in our lifestyles and ecosystems worldwide, the potential health effects of natural environments have grown into a highly pervasive topic. Recent scientific findings suggest beneficial effects from nature exposure on human immune responses. This review aims at providing a comprehensive overview of literature published on immunomodulatory effects of nature exposure by inhalation of natural substances. A systematic database search was performed in SCOPUS and PubMed. The quality and potential bias of included studies (n = 33) were assessed by applying the EPHPP (Effective Public Health Practice Project) tool for human studies and the ARRIVE (Animal Research: Reporting of In Vivo Experiments) and SYRCLE (Systematic Review Centre for Laboratory Animal Experimentation) tools for animal studies. The synthesis of reviewed studies points to positive effects of nature exposure on immunological health parameters; such as anti-inflammatory, anti-allergic, anti-asthmatic effects or increased NK (natural killer) cell activity. Decreased expression of pro-inflammatory molecules, infiltration of leukocytes and release of cytotoxic mediators are outcomes that may serve as a baseline for further studies. However, partially weak study designs evoked uncertainties about outcome reproducibility and key questions remain open concerning effect sizes, duration of exposure and contributions of specific vegetation or ecosystem types.
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影响因子：
2.7
作者：
Bibi, Haim;Reany, Ofer;Keinan, Ehud
通讯作者：
Keinan, Ehud
影响因子：
2.3
作者：
Ahn, Changhwan;Lee, Jae-Hwan;Jeung, Eui-Bae
通讯作者：
Jeung, Eui-Bae
影响因子：
2.3
作者：
Cho KS;Lim YR;Lee K;Lee J;Lee JH;Lee IS
通讯作者：
Lee IS
DOI：
10.1111/j.1742-7843.2010.00622.x
发表时间：
2011-01-01
影响因子：
3.1
作者：
Bastos, Vasco P. D.;Gomes, Antoniella S.;Magalhaes, Pedro J. C.
通讯作者：
Magalhaes, Pedro J. C.
DOI：
10.3390/ijerph110505445
发表时间：
2014-05-19
影响因子：
--
作者：
Haluza D;Schönbauer R;Cervinka R
通讯作者：
Cervinka R