White adipose tissue-derived factors and prostate cancer progression: mechanisms and targets for interventions.
White adipose tissue-derived factors and prostate cancer progression: mechanisms and targets for interventions.
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DOI：
10.1007/s10555-022-10056-0
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发表时间：
2022-09
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影响因子：
--
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--
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肥胖是前列腺癌的一个重要危险因素，导致疾病更具侵袭性，化疗耐药性和死亡率增加。肥胖症中的白色脂肪组织（WAT）过度生长是导致这些临床观察结果的机制的核心。脂肪基质细胞（Adipose stromal cells，ASCs）是WAT中成熟脂肪细胞和其他细胞类型的祖细胞，在驱动PCa侵袭性方面起着至关重要的作用。ASC产生许多因子，特别是趋化因子，包括趋化因子CXCL12，其参与驱动PCa中的EMT和化学抗性。对WAT在肥胖诱导的PCa进展中的影响及其潜在机制的更深入了解，已经开始为制定预防或抵消这些关键事件的干预策略提供机会。这些包括减肥方案、ASC的治疗靶向、卡路里限制模拟化合物的使用和化合物的组合以及特异性受体靶向策略。
Obesity represents an important risk factor for prostate cancer, driving more aggressive disease, chemoresistance and increased mortality. White adipose tissue (WAT) overgrowth in obesity is central to the mechanisms that lead to these clinical observations. Adipose stromal cells (ASCs), the progenitors to mature adipocytes and other cell types in WAT, play a vital role in driving PCa aggressiveness. ASCs produce numerous factors, especially chemokines, including the chemokine CXCL12, which is involved in driving EMT and chemoresistance in PCa. A greater understanding of the impact of WAT in obesity induced progression of PCa and the underlying mechanisms has begun to provide opportunities for developing interventional strategies for preventing or offsetting these critical events. These include weight loss regimens, therapeutic targeting of ASCs, use of calorie restriction mimetic compounds and combinations of compounds as well as specific receptor targeting strategies.
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影响因子：
5.9
作者：
Balaban S;Shearer RF;Lee LS;van Geldermalsen M;Schreuder M;Shtein HC;Cairns R;Thomas KC;Fazakerley DJ;Grewal T;Holst J;Saunders DN;Hoy AJ
通讯作者：
Hoy AJ
影响因子：
29
作者：
Cawthorn WP;Scheller EL;Learman BS;Parlee SD;Simon BR;Mori H;Ning X;Bree AJ;Schell B;Broome DT;Soliman SS;DelProposto JL;Lumeng CN;Mitra A;Pandit SV;Gallagher KA;Miller JD;Krishnan V;Hui SK;Bredella MA;Fazeli PK;Klibanski A;Horowitz MC;Rosen CJ;MacDougald OA
通讯作者：
MacDougald OA
DOI：
10.18632/aging.100455
发表时间：
2012-05
期刊：
Aging
影响因子：
--
作者：
Berstein LM
通讯作者：
Berstein LM
DOI：
10.1073/pnas.1416498111
发表时间：
2014-10-14
影响因子：
11.1
作者：
Ammirante, Massimo;Shalapour, Shabnam;Karin, Michael
通讯作者：
Karin, Michael
影响因子：
5.8
作者：
Bredella, Miriam A.;Fazeli, Pouneh K.;Klibanski, Anne
通讯作者：
Klibanski, Anne