Hearing Loss and Dementia: A Meta-Analysis of Prospective Cohort Studies.
Hearing Loss and Dementia: A Meta-Analysis of Prospective Cohort Studies.
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DOI：
10.3389/fnagi.2021.695117
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发表时间：
2021
影响因子：
4.8
通讯作者：
Gao X
中科院分区：
文献类型：
--
作者：
Liang Z;Li A;Xu Y;Qian X;Gao X
背景：对于听力损失是否是痴呆症的独立危险因素尚缺乏共识。因此，我们进行了一项荟萃分析，以阐明听力损失和痴呆症的关系。方法：通过搜索 PubMed、Embase 和 Cochrane's Library 等电子数据库，纳入前瞻性队列研究，调查社区人群中听力损失与痴呆症发病率之间的关系。采用随机效应模型来合并结果。结果：对 14 个队列（包括 726,900 名参与者）进行了分析。结果表明，听力损失与痴呆独立相关[调整后风险比 (HR)：1.59，95% 置信区间 (CI)：1.37 至 1.86，p < 0.001； I2 = 86%]。依次排除任何个别研究的敏感性分析显示出相似的结果。根据听力损失的诊断方法、痴呆的验证策略、随访时间和载脂蛋白E基因型调整进行的亚组分析也显示出一致的结果（亚组差异的p值均> 0.05）。五项研究的荟萃分析表明，听力损失还与阿尔茨海默病的较高风险有关（调整后 HR：2.24，95% CI：1.32 至 3.79，p = 0.003；I2 = 2%）。结论：听力损失可能会增加成年人患痴呆症的风险。未来应该探讨有效治疗听力损失是否可以降低痴呆症的发病率。
Background: Consensus is lacking with regard to whether hearing loss is an independent risk factor for dementia. We therefore conducted a meta-analysis to clarify the relationship of hearing loss and dementia. Methods: Prospective cohort studies investigating the association between hearing loss and the incidence of dementia in a community-derived population were included by searching electronic databases that included PubMed, Embase, and Cochrane's Library. A random-effects model was adopted to combine the results. Results: Fourteen cohorts including 726,900 participants were analyzed. It was shown that hearing loss was independently associated with dementia [adjusted hazard ratio (HR): 1.59, 95% confidence interval (CI): 1.37 to 1.86, p < 0.001; I2 = 86%]. Sensitivity analysis sequentially excluding any of the individual studies included showed similar results. Subgroup analysis according to the diagnostic methods for hearing loss, validation strategy for dementia, follow-up duration, and adjustment of apolipoprotein E genotype also showed consistent results (p-values for subgroup differences all > 0.05). Meta-analysis with five studies showed that hearing loss was also connected to higher risk of Alzheimer's disease (adjusted HR: 2.24, 95% CI: 1.32 to 3.79, p = 0.003; I2 = 2%). Conclusions: Hearing loss may increase the risk of dementia in the adult population. Whether effective treatment for hearing loss could reduce the incidence of dementia should be explored in the future.
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影响因子：
--
作者：
Lin, Frank R.;Metter, E. Jeffrey;O'Brien, Richard J.;Resnick, Susan M.;Zonderman, Alan B.;Ferrucci, Luigi
通讯作者：
Ferrucci, Luigi
影响因子：
4.9
作者：
Ford, Andrew H.;Hankey, Graeme J.;Almeida, Osvaldo P.
通讯作者：
Almeida, Osvaldo P.
影响因子：
7.7
作者：
Loehler, Jan;Cebulla, Mario;Walther, Leif Erik
通讯作者：
Walther, Leif Erik
DOI：
10.1097/mao.0000000000000313
发表时间：
2014-06
期刊：
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
影响因子：
--
作者：
Gurgel RK;Ward PD;Schwartz S;Norton MC;Foster NL;Tschanz JT
通讯作者：
Tschanz JT
影响因子：
--
作者：
Gates, George A.;Anderson, Melissa L.;McCurry, Susan M.;Feeney, M. Patrick;Larson, Eric B.
通讯作者：
Larson, Eric B.