Associations between lead concentrations and cardiovascular risk factors in U.S. adolescents.
Associations between lead concentrations and cardiovascular risk factors in U.S. adolescents.
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美国青少年铅浓度与心血管危险因素之间的关联
DOI：
10.1038/s41598-017-09701-4
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发表时间：
2017-08-22
影响因子：
4.6
通讯作者：
Mo X
中科院分区：
文献类型：
--
作者：
Xu C;Shu Y;Fu Z;Hu Y;Mo X
环境铅暴露对青少年人群心血管危险因素的影响知之甚少。我们研究了1999-2012年国家健康和营养检查调查（NHANES）中的11，662名受试者。分析血铅水平与心血管危险因素（CVRF）的关系。与CVRF相关的血铅的回归系数（Beta）和95%置信区间（CI）（例如，总胆固醇、HDL-胆固醇、LDL-胆固醇、甘油三酯、空腹血糖、糖化血红蛋白、空腹胰岛素和血压）在校正年龄、性别、种族、血清可替宁、体重指数（BMI）、体力活动和家庭收入后，使用多变量和广义线性回归进行估计。我们发现青少年（年龄12-19岁）血铅（系数= 0.022，95%CI 0.003，0.041; P = 0.022）和LDL-胆固醇之间存在强正相关。然而，在总体人群中未发现与其他CVRF的相关性。在广义线性模型中，与铅水平最低的受试者相比，铅水平最高的受试者的血清LDL-胆固醇升高幅度高1.87%（95% CI 0.73%，3.02%）（趋势p = 0.031）。这些结果提供了流行病学证据，表明低水平的血铅与青少年人群中的LDL-胆固醇呈正相关。
Little is known regarding the effects of environmental lead exposure on cardiovascular risk factors in the adolescent population. We studied 11,662 subjects included in the National Health and Nutrition Examination Survey (NHANES) 1999–2012. Blood lead levels were analysed for their association with cardiovascular risk factors (CVRF). Regression coefficients (Beta) and 95% confidence intervals (CIs) of blood lead in association with CVRF (e.g., total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride, fasting glucose, glycohemoglobin, fasting insulin, and blood pressure) were estimated using multivariate and generalized linear regression after adjusting for age, gender, ethnicity, serum cotinine, body mass index (BMI), physical activity, and household income. We identified a strong positive association between blood lead (coefficient = 0.022, 95% CI 0.003, 0.041; P = 0.022) and LDL-cholesterol in adolescents (age 12–19 years). However, no associations with other CVRFs were found in the overall population. In the generalized linear models, participants with the highest lead levels demonstrated a 1.87% (95% CI 0.73%, 3.02%) greater increase in serum LDL-cholesterol (p for trend = 0.031) when compared to participants with the lowest lead levels. These results provide epidemiological evidence that low levels of blood lead are positively associated with LDL-cholesterol in the adolescent population.
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