Diffuse Optical Spectroscopy Assessment of Resting Oxygen Metabolism in the Leg Musculature.
Diffuse Optical Spectroscopy Assessment of Resting Oxygen Metabolism in the Leg Musculature.
复制标题
腿部肌肉组织静息氧代谢的漫射光谱学评估。
DOI：
10.3390/metabo11080496
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发表时间：
2021-07-29
期刊：
影响因子：
4.1
通讯作者：
Buckley EM
中科院分区：
文献类型：
--
作者：
Boebinger SE;Brothers RO;Bong S;Sanders B;McCracken C;Ting LH;Buckley EM
我们缺乏可靠的方法来持续评估个体之间可比的局部静息状态肌肉活动。近红外光谱（NIRS）提供了一种低成本、无创的方法来评估静脉或动脉闭塞（分别为VO 2 VO和VO 2AO）期间局部、静息状态肌肉氧代谢。然而，该技术不适合连续监测，并且其效用仅限于能够耐受闭塞的患者。将近红外光谱与扩散相关光谱（DCS）相结合，可以连续测量肌肉氧代谢指数（VO 2 i）。尽管缺乏先前的验证，VO 2 i被用作肌肉中氧代谢的量度。在这里，我们的特点测量重复性和比较VO 2 i与VO 2 VO和VO 2AO在内侧腓肠肌（MG）在9名健康成人。VO 2 i、VO 2 VO和VO 2AO的参与者内重复性非常好。VO 2 i与VO 2AO（p = 0.15）和VO 2 VO（p = 0.55）均无显著相关性。这种相关性的缺乏表明，MG中VO 2 i和VO 2AO/VO 2 VO之间的校准系数的变异性在参与者中很大。因此，最好在每次监测会话之前校准VO 2 i。重要的未来工作是需要比较VO 2 i与黄金标准的方式，如正电子发射断层扫描或磁共振成像。
We lack reliable methods to continuously assess localized, resting-state muscle activity that are comparable across individuals. Near-infrared spectroscopy (NIRS) provides a low-cost, non-invasive means to assess localized, resting-state muscle oxygen metabolism during venous or arterial occlusions (VO2VO and VO2AO, respectively). However, this technique is not suitable for continuous monitoring, and its utility is limited to those who can tolerate occlusions. Combining NIRS with diffuse correlated spectroscopy (DCS) enables continuous measurement of an index of muscle oxygen metabolism (VO2i). Despite the lack of previous validation, VO2i is employed as a measure of oxygen metabolism in the muscle. Here we characterized measurement repeatability and compared VO2i with VO2VO and VO2AO in the medial gastrocnemius (MG) in 9 healthy adults. Intra-participant repeatability of VO2i, VO2VO, and VO2AO were excellent. VO2i was not significantly correlated with VO2AO (p = 0.15) nor VO2VO (p = 0.55). This lack of correlation suggests that the variability in the calibration coefficient between VO2i and VO2AO/VO2VO in the MG is substantial across participants. Thus, it is preferable to calibrate VO2i prior to every monitoring session. Important future work is needed to compare VO2i against gold standard modalities such as positron emission tomography or magnetic resonance imaging.
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