Origins of 1/f-like tissue oxygenation fluctuations in the murine cortex.
Origins of 1/f-like tissue oxygenation fluctuations in the murine cortex.
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DOI：
10.1371/journal.pbio.3001298
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发表时间：
2021-07
期刊：
影响因子：
9.8
通讯作者：
Drew PJ
中科院分区：
文献类型：
--
作者：
Zhang Q;Gheres KW;Drew PJ
脑中的氧浓度自发地波动，并且这些波动中的功率分布具有1/f样谱，其中功率谱的低频处存在的功率比高频处高几个数量级。尽管这些振荡已被解释为由神经活动驱动，但这些类似1/f的振荡的起源尚不清楚。在这里，为了深入了解1/f样氧波动的起源，我们研究了清醒行为小鼠的组织氧合和神经活动的动态。我们发现，从小鼠大脑皮层记录的氧信号具有1/f-样谱。然而，带限功率在当地的场电位并没有表现出相应的1/f类波动。当局部神经活动被抑制时，氧浓度的1/f样波动持续存在。红细胞间距波动的双光子测量和数学建模表明，红细胞流量的随机波动可能是氧合中1/f样动力学的基础。这些结果表明，红细胞的离散性及其不规则流动，而不是神经活动的波动，可能会驱动组织氧合的1/f样波动。脑血流动力学信号显示“1/f样”动力学，但它们与神经活动的关系尚不清楚。使用实验和计算方法，这项研究表明，1/f样动力学在脑氧合不反映神经元的活动，而是可以解释的异质性红细胞。
The concentration of oxygen in the brain spontaneously fluctuates, and the distribution of power in these fluctuations has a 1/f-like spectra, where the power present at low frequencies of the power spectrum is orders of magnitude higher than at higher frequencies. Though these oscillations have been interpreted as being driven by neural activity, the origin of these 1/f-like oscillations is not well understood. Here, to gain insight of the origin of the 1/f-like oxygen fluctuations, we investigated the dynamics of tissue oxygenation and neural activity in awake behaving mice. We found that oxygen signal recorded from the cortex of mice had 1/f-like spectra. However, band-limited power in the local field potential did not show corresponding 1/f-like fluctuations. When local neural activity was suppressed, the 1/f-like fluctuations in oxygen concentration persisted. Two-photon measurements of erythrocyte spacing fluctuations and mathematical modeling show that stochastic fluctuations in erythrocyte flow could underlie 1/f-like dynamics in oxygenation. These results suggest that the discrete nature of erythrocytes and their irregular flow, rather than fluctuations in neural activity, could drive 1/f-like fluctuations in tissue oxygenation. Brain hemodynamic signals show "1/f-like" dynamics, but their relationship to neural activity is unclear. Using experimental and computational approaches, this study reveals that 1/f-like dynamics in brain oxygenation do not reflect neuronal activity, but instead may be explained by heterogeneity in red blood cells.
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影响因子：
5.7
作者：
Boynton, Geoffrey M.;Engel, Stephen A.;Heeger, David J.
通讯作者：
Heeger, David J.
DOI：
10.3389/fnene.2010.00008
发表时间：
2010
期刊：
Frontiers in neuroenergetics
影响因子：
--
作者：
Buxton RB
通讯作者：
Buxton RB
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
影响因子：
25
作者：
通讯作者：
--
DOI：
10.1152/ajpheart.1999.277.2.h551
发表时间：
1999-08-01
影响因子：
4.8
作者：
Braun, RD;Lanzen, JL;Dewhirst, MW
通讯作者：
Dewhirst, MW