Review: Environmental influences on alcohol use: Informing research on the joint effects of genes and the environment in diverse U.S. populations.
Review: Environmental influences on alcohol use: Informing research on the joint effects of genes and the environment in diverse U.S. populations.
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DOI：
10.1111/ajad.12478
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发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Kendler KS
中科院分区：
文献类型：
--
作者：
Chartier KG;Karriker-Jaffe KJ;Cummings CR;Kendler KS
本综述旨在了解美国少数民族人群中基因和环境联合影响的酒精研究现状，重点关注非洲裔美国人，拉丁美洲人/西班牙裔，亚洲人和美洲印第安人。进行了关键词和基于作者的检索，并补充了与该领域研究人员的直接联系，以确保全面纳入已发表的同行评议研究。这些研究从所涵盖的种族/民族人群、表型、遗传变异和环境影响方面进行了考虑。本文重点介绍了酒精流行病学的研究结果，为今后的基因-环境关系研究提供了一些潜在的环境变量。对26项（N=26）研究进行了审查。他们主要涉及非洲裔美国人和亚洲人样本，对拉丁美洲人/西班牙裔和美洲印第安人的关注非常有限。有一个广泛的酒精相关的表型检查，研究几乎完全使用候选基因的方法。环境的影响集中在与家人和同伴的最接近的社会网络关系。对社区和社会环境对饮酒影响的研究要少得多。流行病学研究告知选择潜在的环境因素在这些高阶水平建议纳入指标的饮酒规范，酒精供应，社会经济劣势，和不公平的待遇。对现有文献的审查确定了环境研究中的一个关键空白：有必要研究社区和社会层面的暴露情况。这些初步研究提供了一个重要的基础，为发展的对话，并产生其他调查的G-E的关系，在不同的种族/族裔群体。
This review aimed to inform the current state of alcohol research on the joint effects of genes and the environment conducted in U.S. racial/ethnic minority populations, focusing on African Americans, Latinos/Hispanics, Asians, and American Indians. A key-word and author-based search was conducted and supplemented with direct contact to researchers in this area to ensure a comprehensive inclusion of published, peer-reviewed studies. These studies were considered in terms of the racial/ethnic population groups, phenotypes, genetic variants, and environmental influences covered. Research findings from alcohol epidemiologic studies were highlighted to introduce some potential environmental variables for future studies of gene and environment (G–E) relationships. Twenty-six (N=26) studies were reviewed. They predominantly involved African American and Asian samples and had a very limited focus on Latinos/Hispanics and American Indians. There was a wide range of alcohol-related phenotypes examined, and studies almost exclusively used a candidate gene approach. Environmental influences focused on the most proximate social network relationships with family and peers. There was far less examination of community- and societal-level environmental influences on drinking. Epidemiologic studies informing the selection of potential environmental factors at these higher-order levels suggest inclusion of indicators of drinking norms, alcohol availability, socioeconomic disadvantage, and unfair treatment. The review of current literature identified a critical gap in the study of environments: There is the need to study exposures at community and societal levels. These initial studies provide an important foundation for evolving the dialogue and generating other investigations of G–E relationships in diverse racial/ethnic groups.
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DOI：
10.1111/j.1530-0277.2007.00449.x
发表时间：
2007-09-01
影响因子：
3.2
作者：
Buu, Anne;Mansour, MaryAnn;Zucker, Robert A.
通讯作者：
Zucker, Robert A.
影响因子：
5.1
作者：
Borrell, Luisa N.;Roux, Ana V. Diez;Jacobs, David R., Jr.;Shea, Steven;Jackson, Sharon A.;Shrager, Sandi;Blumenthal, Roger S.
通讯作者：
Blumenthal, Roger S.
影响因子：
120.7
作者：
Costello, EJ;Compton, SN;Angold, A
通讯作者：
Angold, A
DOI：
10.15288/jsa.1998.59.659
发表时间：
1998-11-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Caetano, R;Clark, CL
通讯作者：
Clark, CL
影响因子：
4.2
作者：
Caldwell, T. M.;Rodgers, B.;Power, C.
通讯作者：
Power, C.