A corticothalamic switch: controlling the thalamus with dynamic synapses.
A corticothalamic switch: controlling the thalamus with dynamic synapses.
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DOI：
10.1016/j.neuron.2015.03.040
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发表时间：
2015-05-06
期刊：
影响因子：
16.2
通讯作者：
Connors, Barry W.
中科院分区：
文献类型：
--
作者：
Crandall, Shane R.;Cruikshank, Scott J.;Connors, Barry W.
皮质丘脑神经元向丘脑提供大量输入。这种自上而下的投射可能允许皮层通过调节丘脑细胞的兴奋性来调节感觉处理。第6层皮质丘脑神经元单突触兴奋丘脑皮质细胞，但也通过驱动丘脑网状核的抑制细胞间接抑制它们。皮质丘脑的活动通常是抑制还是兴奋丘脑尚不清楚。在这里，我们表明，皮质丘脑的影响是动态的，兴奋-抑制平衡转移的活动依赖性的方式。在低频活动中，皮质丘脑的作用主要是抑制性的，而高频活动（即使是短暂的伽马频率振荡）将皮质丘脑的影响转化为增强。这种切换的机制取决于多个皮质丘脑回路组件之间不同形式的短期突触可塑性。我们的研究结果揭示了一种活动依赖性机制，皮质丘脑神经元可以双向切换丘脑的兴奋性和感觉通量，可能是为了满足不断变化的行为需求。
Corticothalamic neurons provide massive input to the thalamus. This top-down projection may allow cortex to regulate sensory processing by modulating the excitability of thalamic cells. Layer 6 corticothalamic neurons monosynaptically excite thalamocortical cells, but also indirectly inhibit them by driving inhibitory cells of the thalamic reticular nucleus. Whether corticothalamic activity generally suppresses or excites the thalamus remains unclear. Here we show that the corticothalamic influence is dynamic, with the excitatory-inhibitory balance shifting in an activity-dependent fashion. During low-frequency activity corticothalamic effects are mainly suppressive, whereas higher frequency activity (even a short bout of gamma frequency oscillations) converts the corticothalamic influence to enhancement. The mechanism of this switching depends upon distinct forms of short-term synaptic plasticity across multiple corticothalamic circuit components. Our results reveal an activity-dependent mechanism by which corticothalamic neurons can bidirectionally switch the excitability and sensory throughput of the thalamus, possibly to meet changing behavioral demands.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Connors, Barry W.