Manually operatable on-chip bistable pneumatic microstructures for microfluidic manipulations.
Manually operatable on-chip bistable pneumatic microstructures for microfluidic manipulations.
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DOI：
10.1039/c4lc00540f
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发表时间：
2014-09-07
期刊：
影响因子：
6.1
通讯作者：
Pan T
中科院分区：
文献类型：
--
作者：
Chen A;Pan T
双稳态微阀是特别感兴趣的，因为它们独特的性质，只需要在打开和关闭状态之间的过渡期间的能量消耗。随着当代芯片实验室平台从研究环境转移到具有高集成性和小外形的低资源环境，这种特性在减少微流体设备的外部输入数量和控制电路的复杂性方面非常有利。在本文中，我们首先提出了手动操作，芯片上的气动微结构（BPM）的微流体操作。BPM装置的结构设计和操作可以容易地集成到由气动和流体通道组成的任何微流控网络中。它主要由真空激活室（VAC）和压力释放室（PRC）组成，用户可以通过手指按压直接控制在超真空状态（VS）或大气压状态（AS）之间切换。我们已经将多个BPM设备集成到4比1微流体多路复用器中，以演示来自不同来源的片上数字流切换。此外，我们已经在即时诊断芯片中显示了其临床相关性，该芯片处理血液样本以识别芯片上的不同血型（A/B/O）。
Bistable microvalves are of particular interest because of their distinct nature requiring energy consumption only during the transition between the open and closed states. This characteristic can be highly advantageous in reducing the number of external inputs and the complexity of control circuitries for microfluidic devices as contemporary lab-on-a-chip platforms are transferring from research settings to low-resource environments with high integratability and small form factor. In this paper, we first present manually operatable, on-chip bistable pneumatic microstructures (BPM) for microfluidic manipulation. The structural design and operation of the BPM devices can be readily integrated into any pneumatically powered microfluidic network consisting of pneumatic and fluidic channels. It is mainly comprised of a vacuum activation chamber (VAC) and a pressure release chamber (PRC), which users have direct control through finger pressing to switch between bistable vacuum state (VS) or atmospheric state (AS). We have integrated multiple BPM devices into a 4-to-1 microfluidic multiplexor to demonstrate on-chip digital flow switching from different sources. Furthermore, we have shown its clinical relevance in a point-of-care diagnostic chip that process blood samples to identify the distinct blood types (A/B/O) on chip.
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影响因子：
2.7
作者：
Capanu, M;Boyd, JG;Hesketh, PJ
通讯作者：
Hesketh, PJ
挤压芯片：手指控制的微流体网络装置及其在生化分析中的应用
影响因子：
6.1
作者：
Li, Wentao;Chen, Tao;Huang, Yanyi
通讯作者：
Huang, Yanyi
影响因子：
19.6
作者：
通讯作者：
--
影响因子：
8.4
作者：
Grover, WH;Skelley, AM;Mathies, RA
通讯作者：
Mathies, RA
DOI：
10.1088/0960-1317/19/3/037002
发表时间：
2009-03-01
影响因子：
2.3
作者：
Liu, Hao-Bing;Gong, Hai-Qing
通讯作者：
Gong, Hai-Qing