Bioactive Natural Antivirals: An Updated Review of the Available Plants and Isolated Molecules.
Bioactive Natural Antivirals: An Updated Review of the Available Plants and Isolated Molecules.
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DOI：
10.3390/molecules25214878
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发表时间：
2020-10-22
期刊：
影响因子：
--
通讯作者：
Khalid A
中科院分区：
文献类型：
--
作者：
Mohan S;Elhassan Taha MM;Makeen HA;Alhazmi HA;Al Bratty M;Sultana S;Ahsan W;Najmi A;Khalid A
病毒感染和相关疾病是造成世界各地大量死亡和公共卫生问题的原因。每年，全球有350万人死于传染病。当前COVID-19引起的大流行已成为人们一生中最大的健康危害。有许多抗病毒药物和疫苗可用于对抗病毒，但它们也有许多缺点。常规药物有许多副作用，活性突变也会产生对各种病毒的抗药性。这使得科学家们寻找草药作为发现更有效的新抗病毒药物的来源。根据世界卫生组织（WHO）的数据，65%的世界人口正在使用植物和草药作为治疗方式的一部分。此外，植物在药物发现方面具有优势，因为它们被人类长期使用，因此可以预期降低毒性和丰富的生物活性化合物。在这篇综述中，我们强调了重要的病毒，它们的药物靶点和它们的复制周期。我们提供关于最有利的植物提取物及其衍生的植物化学物质对病毒靶点的深入和有见地的信息。我们的主要结论是，植物提取物及其分离的纯化合物是当前病毒感染的重要来源，并可用于未来的挑战。
Viral infections and associated diseases are responsible for a substantial number of mortality and public health problems around the world. Each year, infectious diseases kill 3.5 million people worldwide. The current pandemic caused by COVID-19 has become the greatest health hazard to people in their lifetime. There are many antiviral drugs and vaccines available against viruses, but they have many disadvantages, too. There are numerous side effects for conventional drugs, and active mutation also creates drug resistance against various viruses. This has led scientists to search herbs as a source for the discovery of more efficient new antivirals. According to the World Health Organization (WHO), 65% of the world population is in the practice of using plants and herbs as part of treatment modality. Additionally, plants have an advantage in drug discovery based on their long-term use by humans, and a reduced toxicity and abundance of bioactive compounds can be expected as a result. In this review, we have highlighted the important viruses, their drug targets, and their replication cycle. We provide in-depth and insightful information about the most favorable plant extracts and their derived phytochemicals against viral targets. Our major conclusion is that plant extracts and their isolated pure compounds are essential sources for the current viral infections and useful for future challenges.
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DOI：
10.3390/v9070178
发表时间：
2017-07-10
期刊：
Viruses
影响因子：
--
作者：
Bisignano C;Mandalari G;Smeriglio A;Trombetta D;Pizzo MM;Pennisi R;Sciortino MT
通讯作者：
Sciortino MT
影响因子：
2
作者：
Benzekri, Roudaina;Limam, Ferid;Bouslama, Lamjed
通讯作者：
Bouslama, Lamjed
影响因子：
2.5
作者：
Bachmetov, L.;Gal-Tanamy, M.;Zemel, R.
通讯作者：
Zemel, R.
影响因子：
9.3
作者：
Bekut M;Brkić S;Kladar N;Dragović G;Gavarić N;Božin B
通讯作者：
Božin B
影响因子：
5.4
作者：
Ali, H;König, GM;Kaminsky, R
通讯作者：
Kaminsky, R