Potential of selected Lamiaceae plants in anti(retro)viral therapy.
Potential of selected Lamiaceae plants in anti(retro)viral therapy.
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DOI：
10.1016/j.phrs.2017.12.016
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发表时间：
2018-07
影响因子：
9.3
通讯作者：
Božin B
中科院分区：
文献类型：
--
作者：
Bekut M;Brkić S;Kladar N;Dragović G;Gavarić N;Božin B
对具有抗病毒特性的新药的不断探索常常延伸到天然来源的产品。Lamiaceae是最重要的草本植物科之一，以各种芳香香料的各种生物和药用作用而闻名，包括百里香、薄荷、牛至、罗勒、鼠尾草、咸味、迷迭香、自愈、牛膝草、柠檬香蜂草等。本文综述了迄今为止已证实的植物的抗病毒潜力，重点介绍了抗hiv的特性。通过检索植物名称，结合描述抗病毒活性的关键词，汇编相关文章。抗病毒作用直接，对包膜病毒有明显的活性。病毒生命周期的初始阶段受到的影响最大，因为这些植物似乎主要针对负责附着在靶细胞上的病毒结构。就HIV而言，在病毒生命周期中有一些针对关键酶的活性。即使在耐药的情况下，对应用的草药制剂也有同样的敏感性。一些体内实验表明，利用Lamiaceae代表物可以帮助预防和治疗一些病毒性疾病。减少疾病副作用和常规药物治疗的可能性也是值得进一步研究的一些方面。
Constant search for new drugs with antiviral properties often extends to products of natural origin. Lamiaceae is one of the most important herbal families, well known for various biological and medicinal effects of a variety of aromatic spices, including thyme, mint, oregano, basil, sage, savory, rosemary, self-heal, hyssop, lemon balm and many others. The paper provides a review of antiviral potential of previously mentioned plants which has been demonstrated so far, with special emphasis on anti-HIV properties. Relevant articles were compiled by searching plant names combined with keywords describing antiviral activity. The antiviral effect is direct, with prominent activity against enveloped viral species. Initial stages of the viral life cycle are the most affected, as these plants appear to be targeting mainly viral structures responsible for attachment to target cells. In case of HIV, there is some activity against key enzymes in the viral life cycle. Even in the case of drug resistance, there is an equal susceptibility to applied herbal preparations. Some in vivo experiments suggest that use of Lamiaceae representatives could help in prevention and treatment of some viral diseases. A possible reduction of side effects of diseases and conventional drug therapy are also some aspects worth further investigations.
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影响因子：
7.6
作者：
Abd-Elazem, IS;Chen, HS;Huang, RCC
通讯作者：
Huang, RCC
影响因子：
2.6
作者：
Boubaker-Elandalousi R;Mekni-Toujani M;Kaabi B;Larbi I;Diouani MF;Gharbi M;Akkari H;B'chir F;Ghram A
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作者：
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通讯作者：
Schnitzler, Paul
影响因子：
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作者：
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通讯作者：
Wan, DCC