Evolutionarily conserved network properties of intrinsically disordered proteins.
Evolutionarily conserved network properties of intrinsically disordered proteins.
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DOI：
10.1371/journal.pone.0126729
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Hannenhalli S
中科院分区：
文献类型：
--
作者：
Rangarajan N;Kulkarni P;Hannenhalli S
内含子无序蛋白（IDP）在分离时缺乏稳定的三级结构。然而，值得注意的是，很大一部分国内流离失所者在与其同源伴侣结合后经历了从无序到有序的过渡。结构的灵活性和结合的可塑性使国内流离失所者能够与广泛的合作伙伴互动。然而，尚不清楚哪些更广泛的网络特性可以进一步深入了解国内流离失所者的职能作用。在这里，我们报告的IDP诱导的子网络在多个物种从酵母到人类的网络特性的第一次全面调查。我们的研究结果表明，IDP表现出比预期的模块化，并通过蛋白质连接到蛋白质相互作用网络（PIN）的其余部分，这些蛋白质表现出最高的介数中心性，并连接到比预期少的IDP社区，这表明它们形成了从IDP模块到PIN其余部分的关键通信链接。此外，我们发现，国内流离失所者是丰富的最高层次的监管层次。总的来说，我们的分析揭示了一致的和显着保守的IDP为中心的网络属性，即，模块化的IDP诱导的网络和一层关键节点连接IDP与其余的PIN。
Intrinsically disordered proteins (IDPs) lack a stable tertiary structure in isolation. Remarkably, however, a substantial portion of IDPs undergo disorder-to-order transitions upon binding to their cognate partners. Structural flexibility and binding plasticity enable IDPs to interact with a broad range of partners. However, the broader network properties that could provide additional insights into the functional role of IDPs are not known. Here, we report the first comprehensive survey of network properties of IDP-induced sub-networks in multiple species from yeast to human. Our results show that IDPs exhibit greater-than-expected modularity and are connected to the rest of the protein interaction network (PIN) via proteins that exhibit the highest betweenness centrality and connect to fewer-than-expected IDP communities, suggesting that they form critical communication links from IDP modules to the rest of the PIN. Moreover, we found that IDPs are enriched at the top level of regulatory hierarchy. Overall, our analyses reveal coherent and remarkably conserved IDP-centric network properties, namely, modularity in IDP-induced network and a layer of critical nodes connecting IDPs with the rest of the PIN.
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影响因子：
14.9
作者：
Chatr-Aryamontri A;Breitkreutz BJ;Heinicke S;Boucher L;Winter A;Stark C;Nixon J;Ramage L;Kolas N;O'Donnell L;Reguly T;Breitkreutz A;Sellam A;Chen D;Chang C;Rust J;Livstone M;Oughtred R;Dolinski K;Tyers M
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56.9
作者：
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通讯作者：
Gerstein, Mark B.
影响因子：
64.8
作者：
Jeong, H;Mason, SP;Oltvai, ZN
通讯作者：
Oltvai, ZN