Sex-specific attenuation of impulsive action by progesterone in a go/no-go task for cocaine in rats.
Sex-specific attenuation of impulsive action by progesterone in a go/no-go task for cocaine in rats.
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DOI：
10.1007/s00213-017-4750-2
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发表时间：
2018-01
影响因子：
3.4
通讯作者：
Carroll ME
中科院分区：
文献类型：
--
作者：
Swalve N;Smethells JR;Younk R;Mitchell J;Dougen B;Carroll ME
先前的研究表明，孕酮(PRO)减少了雌性大鼠对可卡因的冲动选择，但雄性大鼠没有。冲动行为通常是通过在天然强化剂不可用的信号期间对强化剂做出反应来衡量的，它预测动物和人类使用药物的开始和升级。本研究考察了孕酮(PRO)对雄性和雌性大鼠在GO/NO-GO任务中对可卡因的冲动行为。对大鼠进行Go/No-Go任务训练，以对可卡因注射(0.4 mg/kg/inf)做出反应。在“去”部分，反应被强化在VI 30-S时间表上；而在“不去”部分，抑制反应被强化在差异强化的其他行为(DRO)30-S时间表上。禁止组件期间的响应将重置DRO计时器，并用作冲动行为的衡量标准。在建立基线反应后，用VEH或PRO(0.5 mg/kg)对大鼠进行预处理，并比较雄性和雌性大鼠在GO组分对可卡因的DRO重置和反应。在雌性大鼠中，经过PRO治疗后的DRO重置显著低于VEH，但雄性大鼠没有。无论是女性还是男性，PRO在GO部分的应答率和总输液量都没有明显改变。使用PRO治疗后，对可卡因的冲动行为因性别而异减少，而不影响可卡因的自我给药。
Previous work indicated that progesterone (PRO) reduced impulsive choice for cocaine in female but not male rats. Impulsive action, typically measured by responding for a reinforcer during a signaled period of nonavailability of natural reinforcers, predicts initiation and escalation of drug use in animals and humans. The present study examined impulsive action for cocaine using progesterone (PRO) in male and female rats trained on a Go/No-go task. Rats were trained on a Go/No-go task to respond for cocaine infusions (0.4 mg/kg/inf). During the “Go” component, responding was reinforced on a VI 30-s schedule; whereas, during the “No-Go” component withholding a response was reinforced on a differential reinforcement of other behavior (DRO) 30-s schedule. A response during the No-go component reset the DRO timer and served as a measure of impulsive action. After baseline responding was established, rats were pretreated with vehicle (VEH) or PRO (0.5 mg/kg), and DRO resets and responding during the Go component for cocaine were compared in males vs. females. DRO resets were significantly lower following PRO treatment compared to VEH in female, but not male, rats. Response rates and overall infusions during the Go component were not significantly altered by PRO in either females or males. Treatment with PRO resulted in a sex-specific reduction in impulsive action for cocaine, while not affecting cocaine self-administration.
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