Associations of dietary antioxidant micronutrients with the prevalence of obesity in adults.
Associations of dietary antioxidant micronutrients with the prevalence of obesity in adults.
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DOI：
10.3389/fnut.2023.1098761
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发表时间：
2023
影响因子：
5
通讯作者：
Ma, Lin
中科院分区：
文献类型：
--
作者：
Yang, Yazhu;Xu, Haifeng;Zhang, Yi;Chen, Lin;Tian, Chengzi;Huang, Bihui;Chen, Youpeng;Ma, Lin
抗氧化微量营养素在肥胖的临床治疗中具有治疗潜力。然而，目前还没有研究调查膳食抗氧化剂的复杂水平与肥胖之间的关系。我们的主要目的是利用国家健康与营养检查调查（NHANES）的数据库来调查抗氧化剂组合与肥胖之间的关系。本横断面研究包括2005年至2018年对41,021人（≥18岁）的调查。采用多变量logistic和加权分位数和（WQS）回归来调查这些抗氧化剂（无论是单独的还是集体的）与肥胖患病率之间的关系。限制三次样条（RCS）回归也被用来分析这些关联的线性。根据多变量逻辑模型，我们发现最高四分位数的大多数抗氧化剂水平与较低的肥胖患病率独立相关，而硒的结果相反（p表示趋势<0.05）。WQS指数显示，11种抗氧化剂与肥胖和腹部肥胖患病率呈负相关（均p<0.001），其中铁/维生素C在抗氧化剂复合物与肥胖和腹部肥胖的负相关中权重最大。RCS回归结果显示，视黄醇、维生素A、α-胡萝卜素、β-胡萝卜素、β-隐黄质、维生素C、铁和铜与肥胖均呈非线性相关。阈值效应分析表明，视黄醇、维生素A、α-胡萝卜素、β-胡萝卜素、β-隐黄质、维生素C、铁和铜的拐点分别为235.57、374.81、58.89、891.44、30.70、43,410、11,240.00和990.00 μg/d。我们的研究发现，高水平的11种膳食抗氧化剂复合物与较低的肥胖和腹部肥胖患病率有关，在这种反向关联中，铁和维生素C的重量最大。
Antioxidant micronutrients have a therapeutic potential for clinical treatment of obesity. NO research, however, has examined the connection between the complex level of dietary antioxidants and obesity. We mainly aimed to investigate the relationship between a combination of antioxidants and obesity using the database of the national health and nutrition examination survey (NHANES). This cross-sectional study contains a survey of 41,021 people (≥18 years) in total ranging from 2005 to 2018. Multivariate logistic and weighted quantile sum (WQS) regression were performed to investigate the associations between these antioxidants, both individually and collectively, and the prevalence of obesity. The restricted cubic spline (RCS) regression was also utilized to analyze the linearity of these associations. According to multivariate logistic models, we found that the levels of most antioxidants in the highest quartile were independently related to a lower prevalence of obesity, while a reverse result was observed in selenium (p for trend <0.05). The WQS index revealed that a total of the 11 antioxidants is negatively related to the prevalence of obesity and abdominal obesity (all p<0.001), and iron/vitamin C have the greatest weight in the negative associations between antioxidant complex and obesity, as well as abdominal obesity. In addition, the RCS regression showed that retinol, vitamin A, α-carotene, β-carotene, β-cryptoxanthin, vitamin C, iron, and copper all had a non-linear association with obesity. Threshold effect analysis demonstrated that the inflection points of retinol, vitamin A, α-carotene, β-carotene, β-cryptoxanthin, vitamin C, iron, and cooper were 235.57, 374.81, 58.89, 891.44, 30.70, 43,410.00, 11,240.00, and 990.00 μg/day, respectively. Our study found that a high level of a complex of 11 dietary antioxidants is related to a lower prevalence of obesity and abdominal obesity, among this inverse associations iron and vitamin C have the greatest weight.
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影响因子：
5.6
作者：
Fukunaka A;Fujitani Y
通讯作者：
Fujitani Y
影响因子：
3.7
作者：
Laillou A;Yakes E;Le TH;Wieringa FT;Le BM;Moench-Pfanner R;Berger J
通讯作者：
Berger J
DOI：
10.1016/j.jtemb.2021.126718
发表时间：
2021-01-20
影响因子：
3.5
作者：
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通讯作者：
Dang, Ajay Kumar
影响因子：
4.7
作者：
Galan, P;Viteri, FE;Hercberg, S
通讯作者：
Hercberg, S
影响因子：
3.5
作者：
Castillo JJ;Orlando RA;Garver WS
通讯作者：
Garver WS