Gene-nutrient interactions and susceptibility to human obesity.
Gene-nutrient interactions and susceptibility to human obesity.
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DOI：
10.1186/s12263-017-0581-3
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发表时间：
2017
影响因子：
3.5
通讯作者：
Garver WS
中科院分区：
文献类型：
--
作者：
Castillo JJ;Orlando RA;Garver WS
在世界各地不同人群中进行的大量全基因组关联研究、可转移性研究和候选基因研究已经确定了与常见人类肥胖相关的基因变异。越来越多的证据表明，这些肥胖基因变异与多种环境因素相互作用，增加了对这种复杂代谢疾病的易感性。这篇综述文章的目的是提供简明和更新的信息能量平衡，体重的遗传性，基因变异的起源，以及与人类肥胖相关的基因-营养素相互作用。建议这些相关主题的知识将提供有价值的见解，为未来的预防性生活方式干预，有针对性的营养和药物治疗。
A large number of genome-wide association studies, transferability studies, and candidate gene studies performed in diverse populations around the world have identified gene variants that are associated with common human obesity. The mounting evidence suggests that these obesity gene variants interact with multiple environmental factors and increase susceptibility to this complex metabolic disease. The objective of this review article is to provide concise and updated information on energy balance, heritability of body weight, origins of gene variants, and gene-nutrient interactions in relation to human obesity. It is proposed that knowledge of these related topics will provide valuable insight for future preventative lifestyle intervention using targeted nutritional and medicinal therapies.
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影响因子：
158.5
作者：
BOUCHARD, C;TREMBLAY, A;FOURNIER, G
通讯作者：
FOURNIER, G
影响因子：
--
作者：
Corella, Dolores;Peloso, Gina;Arnett, Donna K.;Demissie, Serkalem;Cupples, L. Adrienne;Tucker, Katherine;Lai, Chao-Qiang;Parnell, Laurence D.;Coltell, Oscar;Lee, Yu-Chi;Ordovas, Jose M.
通讯作者：
Ordovas, Jose M.
影响因子：
7.1
作者：
Bauer, Florianne;Elbers, Clara C.;van der Schouw, Yvonne T.
通讯作者：
van der Schouw, Yvonne T.
影响因子：
30.8
作者：
Bradfield, Jonathan P.;Taal, H. Rob;Timpson, Nicholas J.;Scherag, Andre;Lecoeur, Cecile;Warrington, Nicole M.;Hypponen, Elina;Holst, Claus;Valcarcel, Beatriz;Thiering, Elisabeth;Salem, Rany M.;Schumacher, Fredrick R.;Cousminer, Diana L.;Sleiman, Patrick M. A.;Zhao, Jianhua;Berkowitz, Robert I.;Vimaleswaran, Karani S.;Jarick, Ivonne;Pennell, Craig E.;Evans, David M.;St Pourcain, Beate;Berry, Diane J.;Mook-Kanamori, Dennis O.;Hofman, Albert;Rivadeneira, Fernando;Uitterlinden, Andre G.;van Duijn, Cornelia M.;van der Valk, Ralf J. P.;de Jongste, Johan C.;Postma, Dirkje S.;Boomsma, Dorret I.;Gauderman, W. James;Hassanein, Mohamed T.;Lindgren, Cecilia M.;Magi, Reedik;Boreham, Colin A. G.;Neville, Charlotte E.;Moreno, Luis A.;Elliott, Paul;Pouta, Anneli;Hartikainen, Anna-Liisa;Li, Mingyao;Raitakari, Olli;Lehtimaki, Terho;Eriksson, Johan G.;Palotie, Aarno;Dallongeville, Jean;Das, Shikta;Deloukas, Panos;McMahon, George;Ring, Susan M.;Kemp, John P.;Buxton, Jessica L.;Blakemore, Alexandra I. F.;Bustamante, Mariona;Guxens, Monica;Hirschhorn, Joel N.;Gillman, Matthew W.;Kreiner-Moller, Eskil;Bisgaard, Hans;Gilliland, Frank D.;Heinrich, Joachim;Wheeler, Eleanor;Barroso, Ines;O'Rahilly, Stephen;Meirhaeghe, Aline;Sorensen, Thorkild I. A.;Power, Chris;Palmer, Lyle J.;Hinney, Anke;Widen, Elisabeth;Farooqi, I. Sadaf;McCarthy, Mark I.;Froguel, Philippe;Meyre, David;Hebebrand, Johannes;Jarvelin, Marjo-Riitta;Jaddoe, Vincent W. V.;Smith, George Davey;Hakonarson, Hakon;Grant, Struan F. A.
通讯作者：
Grant, Struan F. A.
DOI：
10.1111/j.1651-2227.1976.tb04887.x
发表时间：
1976-01-01
期刊：
ACTA PAEDIATRICA SCANDINAVICA
影响因子：
--
作者：
BORJESON, M
通讯作者：
BORJESON, M