Differential Roles of the Salience Network During Prediction Error Encoding and Facial Emotion Processing Among Female Adolescent Assault Victims.
Differential Roles of the Salience Network During Prediction Error Encoding and Facial Emotion Processing Among Female Adolescent Assault Victims.
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DOI：
10.1016/j.bpsc.2018.08.014
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发表时间：
2019-04
期刊：
影响因子：
--
通讯作者：
Kilts CD
中科院分区：
文献类型：
--
作者：
Cisler JM;Esbensen K;Sellnow K;Ross M;Weaver S;Sartin-Tarm A;Herringa RJ;Kilts CD
早期生活中的攻击性暴力暴露是创伤后应激障碍和其他情绪和焦虑障碍的一个潜在风险因素。神经回路模型认为，风险增加是由包括背侧前扣带皮质、前岛和杏仁核在内的突出网络中情绪处理的增强所介导的。然而，强化学习(RL)的过程也涉及显著网络，并涉及对早期生活创伤和创伤后应激障碍的反应。为了确定它们在应对早期生活创伤和创伤后应激障碍症状中的相对作用，本研究比较了情绪处理过程中显著网络的参与和强化学习作为早期生活攻击暴露的功能。年龄在11-17岁的青春期女孩(n=30，身体或性侵犯；n=30，健康对照)在fMRI中完成两个任务：面部情绪处理任务和使用社会或非社会刺激的RL任务。独立成分分析被用来识别显著网络并表征其对情绪加工和预测误差(PE)编码的参与程度。攻击与情绪处理过程中显著网络的更大反应性有关。相比之下，我们发现，被攻击的女孩在显著网络中表现出较少的负面PE编码，特别是在社交RL任务中。情绪加工和PE编码过程中的显著网络活动障碍与创伤后应激障碍症状无关。这些结果表明，在创伤暴露的年轻人中，显著网络的高活性与低活性依赖于认知-情感领域。
Early life assaultive violence exposure is a potent risk factor for PTSD and other mood and anxiety disorders. Neurocircuitry models posit that increased risk is mediated by heightened emotion processing in a salience network including dorsal anterior cingulate cortex, anterior insula, and amygdala. However, the processes of reinforcement learning (RL) also engage the salience network and are implicated in responses to early life trauma and PTSD. To define their relative roles in response to early life trauma and PTSD symptoms, the current study compared engagement of the salience network during emotion processing and reinforcement learning as a function of early life assault exposure. Adolescent girls (n=30 physically or sexually assaulted; n = 30 healthy comparison) aged 11–17 completed two tasks during fMRI: a facial emotion processing task and RL tasks using either social or non-social stimuli. Independent component analysis was used to identify a salience network and characterize its engagement in response to emotion processing and prediction error (PE) encoding during the RL tasks. Assault was related to greater reactivity of the salience network during emotion processing. By contrast, we found that assaulted girls demonstrated lesser encoding of negative PEs in the salience network, particularly during the social RL tasks. The dysfunction of salience network activity during emotion processing and PE encoding was not associated with PTSD symptoms. These results suggest that hyper- vs hypo-activity of the salience network among trauma-exposed youth depends on the cognitive-affective domain.
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