The interplay of additivity, dominance, and epistasis on fitness in a diploid yeast cross.
The interplay of additivity, dominance, and epistasis on fitness in a diploid yeast cross.
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二倍体酵母杂交中加性、显性和上位性对适合度的相互作用。
DOI：
10.1038/s41467-022-29111-z
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发表时间：
2022-03-18
影响因子：
16.6
通讯作者：
Ehrenreich IM
中科院分区：
文献类型：
--
作者：
Matsui T;Mullis MN;Roy KR;Hale JJ;Schell R;Levy SF;Ehrenreich IM
In diploid species, genetic loci can show additive, dominance, and epistatic effects. To characterize the contributions of these different types of genetic effects to heritable traits, we use a double barcoding system to generate and phenotype a panel of ~200,000 diploid yeast strains that can be partitioned into hundreds of interrelated families. This experiment enables the detection of thousands of epistatic loci, many whose effects vary across families. Here, we show traits are largely specified by a small number of hub loci with major additive and dominance effects, and pervasive epistasis. Genetic background commonly influences both the additive and dominance effects of loci, with multiple modifiers typically involved. The most prominent dominance modifier in our data is the mating locus, which has no effect on its own. Our findings show that the interplay between additivity, dominance, and epistasis underlies a complex genotype-to-phenotype map in diploids. Heritable traits can be affected by additive, dominance, and epistatic effects at genetic loci. Here, the authors use chromosomally-encoded barcodes to perform linkage mapping in diploid cross progeny in budding yeast, finding that epistasis in diploids frequently modifies both additivity and dominance.
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影响因子：
14.8
作者：
Gietz, R. Daniel;Schiestl, Robert H.
通讯作者：
Schiestl, Robert H.
影响因子：
2.5
作者：
Churchill, Gary A.;Gatti, Daniel M.;Munger, Steven C.;Svenson, Karen L.
通讯作者：
Svenson, Karen L.
影响因子：
64.5
作者：
Boyle EA;Li YI;Pritchard JK
通讯作者：
Pritchard JK
影响因子：
16.6
作者：
Bloom JS;Kotenko I;Sadhu MJ;Treusch S;Albert FW;Kruglyak L
通讯作者：
Kruglyak L
影响因子：
64.5
作者：
JULIUS, D;BLAIR, L;THORNER, J
通讯作者：
THORNER, J