Activation of oxytocin receptors, but not arginine-vasopressin V1a receptors, in the ventral tegmental area of male Syrian hamsters is essential for the reward-like properties of social interactions.
Activation of oxytocin receptors, but not arginine-vasopressin V1a receptors, in the ventral tegmental area of male Syrian hamsters is essential for the reward-like properties of social interactions.
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DOI：
10.1016/j.psyneuen.2016.09.001
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发表时间：
2016-12
影响因子：
3.7
通讯作者：
Albers HE
中科院分区：
文献类型：
--
作者：
Song Z;Borland JM;Larkin TE;O'Malley M;Albers HE
社会奖励在塑造人类和动物行为方面起着重要作用。许多形式的社会行为，包括性行为、父母行为和社会游戏的奖励性质，已经通过诸如条件位置偏好测试等完善的程序揭示出来。非肽催产素（OT）和精氨酸抗利尿素（AVP）通过其在多个脑结构中的作用来调节许多有动机的社会行为。有趣的是，关于OT或AVP是否会通过其在腹侧被盖区（VTA）等奖励机制中起关键作用的大脑结构中的行为来促进社会互动的奖励特性的数据很少。本研究的目的是探讨OT和AVP在VTA中调节社会互动的奖励特性的作用。两只雄性仓鼠之间的社会互动减少了注射生理盐水的仓鼠自发的避地行为。然而，有趣的是，注射到VTA的OT和AVP诱导了社会互动室的场所回避率显著降低了两倍。最后，由于OT和AVP可以相互作用于彼此的受体来影响社会行为，我们还注射了高选择性的OTR和V1aR激动剂和拮抗剂，以确定OT或AVP V1a受体是否负责介导这些神经肽对社会奖励的影响。我们的研究结果不仅证明了OT和AVP激活OTRs而不是v1ar来介导社会奖励，还证明了VTA中OT受体的激活对于社会互动的奖励特性的表达至关重要。
Social reward plays a fundamental role in shaping human and animal behavior. The rewarding nature of many forms of social behavior including sexual behavior, parental behavior, and social play has been revealed using well-established procedures such as the conditioned place preference test. Many motivated social behaviors are regulated by the nonapeptides oxytocin (OT) and arginine vasopressin (AVP) through their actions in multiple brain structures. Interestingly, there are few data on whether OT or AVP might contribute to the rewarding properties of social interaction by their actions within brain structures that play a key role in reward mechanisms such as the ventral tegmental area (VTA). The goal of the present study was to investigate the role of OT and AVP in the VTA in regulating the reward-like properties of social interactions. Social interactions between two male hamsters reduced a spontaneous place avoidance in hamsters injected with saline control. Interestingly, however, OT and AVP injected into the VTA induced a significant two-fold reduction in place avoidance for the social interaction chamber when compared to control injections of vehicle. Finally, because OT and AVP can act on each other’s receptors to influence social behavior, we also injected highly selective OTR and V1aR agonists and antagonists to determine whether OT or AVP V1a receptors were responsible for mediating the effects of these neuropeptides on social reward. Our results not only demonstrated that OT and AVP activate OTRs and not V1aRs to mediate social reward, they also demonstrated that the activation of OT receptors in the VTA is essential for the expression of the rewarding properties of social interactions.
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影响因子：
3
作者：
Aragona BJ;Wang Z
通讯作者：
Wang Z
影响因子：
7.4
作者：
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通讯作者：
Albers, H. Elliott
影响因子：
3.5
作者：
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通讯作者：
Huhman, Kim L.
影响因子：
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作者：
Albers, HE;Dean, A;Huhman, KL
通讯作者：
Huhman, KL
影响因子：
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作者：
HUGUENIN, RL
通讯作者：
HUGUENIN, RL