Is cesarean section delivery associated with autism spectrum disorder?
Is cesarean section delivery associated with autism spectrum disorder?
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DOI：
10.17712/nsj.2019.1.20180303
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发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Zeidan ZA
中科院分区：
文献类型：
--
作者：
Al-Zalabani AH;Al-Jabree AH;Zeidan ZA
探讨剖腹产与自闭症谱系障碍（ASD）之间的相关性。2016年在沙特阿拉伯王国Al-Madina Al-Munawarah市进行了一项病例对照研究，病例与对照比例为1：2。根据合格标准选择病例，并选择在同一医院的健康婴儿诊所就诊的儿童作为对照组受试者。从医疗记录中收集数据，并对母亲进行基于访谈的问卷调查。采用卡方检验进行双变量分析和logistic回归，以估计粗比值比和调整后比值比（OR）。87例ASD患者和174例对照组受试者被纳入本研究。在87名ASD患儿中，约39%（n=34）通过剖宫产分娩，而对照组174名患儿中有21%（n=36）通过剖宫产分娩。调整潜在混杂因素后，调整后的OR为2.9（95%置信区间[CI]：1.57-5.35）。在这项研究中发现了剖宫产和ASD之间的关联，支持了其他研究的结果。建议采取预防措施，避免不必要的剖宫产。
To investigate a correlation between birth by caesarean section and autism spectrum disorder (ASD). A case-control study with a case to control ratio of 1:2 was performed in Al-Madina Al-Munawarah city, Kingdom of Saudi Arabia during the year 2016. The cases were selected according to the eligibility criteria and children attending a well-baby clinic in the same hospital, were chosen as the control group subjects. Data was collected from the medical records and an interview-based questionnaire was administered to the mothers. The chi-square test was used for bivariate analysis and logistic regression to estimate the crude and adjusted odds ratios (ORs). Eighty-seven cases of ASD and 174 control group subjects were included in the current study. Approximately 39% (n=34) of the 87 children with ASD were delivered by cesarean section compared to 21% (n=36) of the 174 children in the control group. After adjusting for potentially confounding factors, the adjusted OR was 2.9 (95% confidence interval [CI]: 1.57-5.35). An association between delivery by cesarean section and ASD was found in this study, in support of the findings of other studies. It is recommended that preventive measures are adopted to avoid unnecessary cesarean sections.
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影响因子：
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作者：
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