Demonstrating the Potential of Using Bio-Based Sustainable Polyester Blends for Bone Tissue Engineering Applications.
Demonstrating the Potential of Using Bio-Based Sustainable Polyester Blends for Bone Tissue Engineering Applications.
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DOI：
10.3390/bioengineering9040163
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发表时间：
2022-04-06
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--
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众所周知，医疗保健应用对环境有相当大的影响，生物基聚合物的使用已成为减少该领域碳足迹的有力方法。本研究旨在探索使用新的可持续聚酯混合物（Floreon™）作为支架的适用性，以帮助肌肉骨骼应用。肌肉骨骼问题源于与骨骼和关节有关的各种疾病和损伤。具体而言，骨损伤可能由创伤、癌症或长期感染引起，目前在发达国家和发展中国家都被认为是一个主要的全球性问题。在这项工作中，我们使用熔融沉积建模（FDM）从新型生物聚合物混合物中制造了一系列3D打印结构，并且我们使用生物陶瓷（硅灰石，15%w/w）对这些材料进行了改性。我们已经评估了他们的性能在体外使用人真皮成纤维细胞和大鼠间充质基质细胞。这种新型可持续混合物具有生物相容性，与PLA对照品相比，在1-18天内细胞代谢活性没有差异。FloreonTM共混物已被证明是一种有前途的材料，可用于骨组织再生，因为它显示出与天然骨相同的冲击强度（略低于10 kJ/m2），并且在用硅灰石改性时支持成骨活性的改善。
Healthcare applications are known to have a considerable environmental impact and the use of bio-based polymers has emerged as a powerful approach to reduce the carbon footprint in the sector. This research aims to explore the suitability of using a new sustainable polyester blend (Floreon™) as a scaffold directed to aid in musculoskeletal applications. Musculoskeletal problems arise from a wide range of diseases and injuries related to bones and joints. Specifically, bone injuries may result from trauma, cancer, or long-term infections and they are currently considered a major global problem in both developed and developing countries. In this work we have manufactured a series of 3D-printed constructs from a novel biopolymer blend using fused deposition modelling (FDM), and we have modified these materials using a bioceramic (wollastonite, 15% w/w). We have evaluated their performance in vitro using human dermal fibroblasts and rat mesenchymal stromal cells. The new sustainable blend is biocompatible, showing no differences in cell metabolic activity when compared to PLA controls for periods 1–18 days. FloreonTM blend has proven to be a promising material to be used in bone tissue regeneration as it shows an impact strength in the same range of that shown by native bone (just under 10 kJ/m2) and supports an improvement in osteogenic activity when modified with wollastonite.
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影响因子：
5.6
作者：
Gregor A;Filová E;Novák M;Kronek J;Chlup H;Buzgo M;Blahnová V;Lukášová V;Bartoš M;Nečas A;Hošek J
通讯作者：
Hošek J
影响因子：
8.1
作者：
Charoenlarp P;Rajendran AK;Iseki S
通讯作者：
Iseki S
影响因子：
2.4
作者：
SAHA, S;HAYES, WC
通讯作者：
HAYES, WC
影响因子：
9.7
作者：
Rahaman, Mohamed N.;Day, Delbert E.;Bal, B. Sonny;Fu, Qiang;Jung, Steven B.;Bonewald, Lynda F.;Tomsia, Antoni P.
通讯作者：
Tomsia, Antoni P.
DOI：
10.1016/j.jobcr.2019.10.004
发表时间：
2020-01-01
影响因子：
--
作者：
Dwivedi, Ruby;Pandey, Rahul;Mehrotra, Divya
通讯作者：
Mehrotra, Divya