New Insights Into Microbiota Modulation-Based Nutritional Interventions for Neurodevelopmental Outcomes in Preterm Infants.
New Insights Into Microbiota Modulation-Based Nutritional Interventions for Neurodevelopmental Outcomes in Preterm Infants.
复制标题
DOI：
10.3389/fmicb.2021.676622
复制
发表时间：
2021
影响因子：
5.2
通讯作者：
Le Huërou-Luron I
中科院分区：
文献类型：
--
作者：
Buffet-Bataillon S;Bellanger A;Boudry G;Gangneux JP;Yverneau M;Beuchée A;Blat S;Le Huërou-Luron I
肠道微生物群和中枢神经系统在产前和产后具有平行的发育窗口。越来越多的证据表明，早产儿肠道菌群失调会使新生儿在以后的生活中容易出现不良的神经系统结果。了解肠道微生物群定植与大脑发育之间的联系，以定制旨在优化初始定植和微生物群发育的治疗方法，是保证早产儿充分大脑发育和增强神经系统结果的有希望的策略。母乳喂养与早产儿的充分认知发展和健康微生物群有关。婴儿配方奶粉是工业生产的婴儿营养替代品，不能完全概括母乳喂养的益处，并且可以通过了解母乳成分对肠道微生物群的作用来大大改善。在这篇综述中，我们将首先讨论母乳成分的营养和生物活性成分信息及其对早产儿新生儿肠道微生物群组装的贡献。然后我们将讨论连接肠道微生物群和大脑发育的新兴途径。最后，我们将讨论基于微生物群调节的有前景的营养干预措施（包括婴儿配方奶粉和母体营养中补充益生菌和益生元），以改善神经发育结果。
Gut microbiota and the central nervous system have parallel developmental windows during pre and post-natal life. Increasing evidences suggest that intestinal dysbiosis in preterm infants predisposes the neonate to adverse neurological outcomes later in life. Understanding the link between gut microbiota colonization and brain development to tailor therapies aimed at optimizing initial colonization and microbiota development are promising strategies to warrant adequate brain development and enhance neurological outcomes in preterm infants. Breast-feeding has been associated with both adequate cognitive development and healthy microbiota in preterms. Infant formula are industrially produced substitutes for infant nutrition that do not completely recapitulate breast-feeding benefices and could be largely improved by the understanding of the role of breast milk components upon gut microbiota. In this review, we will first discuss the nutritional and bioactive component information on breast milk composition and its contribution to the assembly of the neonatal gut microbiota in preterms. We will then discuss the emerging pathways connecting the gut microbiota and brain development. Finally, we will discuss the promising microbiota modulation-based nutritional interventions (including probiotic and prebiotic supplementation of infant formula and maternal nutrition) for improving neurodevelopmental outcomes.
登录
查看更多内容
影响因子：
5.9
作者：
Barrera C;Valenzuela R;Chamorro R;Bascuñán K;Sandoval J;Sabag N;Valenzuela F;Valencia MP;Puigrredon C;Valenzuela A
通讯作者：
Valenzuela A
影响因子：
2.6
作者：
Ballard, Olivia;Morrow, Ardythe L.
通讯作者：
Morrow, Ardythe L.
影响因子：
4.6
作者：
Boix-Amorós A;Martinez-Costa C;Querol A;Collado MC;Mira A
通讯作者：
Mira A
影响因子：
30.3
作者：
Backhed, Fredrik;Roswall, Josefine;Jun, Wang
通讯作者：
Jun, Wang
影响因子：
4.4
作者：
Al Khalaf, Sukainah Y.;O'Neill, Sinead M.;Khashan, Ali S.
通讯作者：
Khashan, Ali S.