Cocaine selectively increases proliferation in the adult murine hippocampus.
Cocaine selectively increases proliferation in the adult murine hippocampus.
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DOI：
10.1016/j.neulet.2010.08.080
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发表时间：
2010-11-19
影响因子：
2.5
通讯作者：
Smeyne RJ
中科院分区：
文献类型：
--
作者：
Lloyd SA;Balest ZR;Corotto FS;Smeyne RJ
Cocaine abuse continues to be a significant problem in the USA and elsewhere. Cocaine is an indirect agonist for dopamine, norepinephrine and serotonin with numerous potential downstream effects, including processes and signals associated with adult neurogenesis. Since drug addiction is associated with brain plasticity, we hypothesized that cocaine exposure would alter cellular proliferation in two adult neurogenic regions (the subventricular and subgranular zones). We used bromodeoxyuridine (BrdU) to track newly generated cells in the brains of adult mice after chronic cocaine or saline exposures. No differences were found in the number or migration patterns of BrdU-labeled cells in the forebrain neurogenic areas. However, cocaine produced a significant increase in the number of hippocampal BrdU-labeled cells.
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影响因子：
16.2
作者：
Fanselow, Michael S.;Dong, Hong-Wei
通讯作者：
Dong, Hong-Wei
影响因子：
3.6
作者：
Middaugh, LD;Boggan, WO;Xu, WD
通讯作者：
Xu, WD
DOI：
10.1073/pnas.120552597
发表时间：
2000-06-20
影响因子：
11.1
作者：
Eisch, AJ;Barrot, M;Nestler, EJ
通讯作者：
Nestler, EJ
影响因子：
8.2
作者：
Balu, Darrick T.;Lucki, Irwin
通讯作者：
Lucki, Irwin
影响因子：
3.3
作者：
Brezun, JM;Daszuta, A
通讯作者：
Daszuta, A