Photoacoustic imaging of in vivo hemodynamic responses to sodium nitroprusside.
Photoacoustic imaging of in vivo hemodynamic responses to sodium nitroprusside.
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DOI：
10.1002/jbio.202000478
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发表时间：
2021-07
影响因子：
2.8
通讯作者：
Yao J
中科院分区：
文献类型：
--
作者：
Zhang D;Li R;Chen M;Vu T;Sheng H;Yang W;Hoffmann U;Luo J;Yao J
尚未很好地研究了一种广泛使用的降压药（SNP）（SNP）的体内血流动力学影响。在这里，我们应用了功能性光学分辨率光声显微镜（OR-PAM）来研究体内小鼠SNP的血液动力学反应。如预期的那样，在使用SNP之后，全身血压降低了53％。 OR-PAM结果表明，SNP在大脑和皮肤中分别诱导了24％和23％的动脉血管舒张。在大脑和皮肤中也观察到静脉血管舒张较弱，为9％和5％。结果显示了两种不同类型的血液氧合反应。在血液氧合降低的小鼠中，大脑的动脉氧合和静脉氧合分别降低了6％和13％，皮肤中的动脉氧合和静脉氧合作用分别降低了7％和18％。在血液氧合增加的小鼠中，大脑中的动脉氧合和静脉氧合升高了4％和22％，皮肤中的动脉氧合和静脉氧合升高了1％和9％。我们观察到静脉变化清楚地落在了皮肤中的动脉变化，但没有在大脑中。我们的结果共同显示了SNP引起的全身血压，血管大小和血液氧合的变化之间的相关性。
将功能性光声显微镜用于研究体内小鼠中对亚硝普钠（SNP）的血液动力学反应。 SNP在脑和耳朵中诱导动脉和静脉血管舒张。大多数动物的血液氧合减少，而其他动物的含量有所增加。我们观察到SNP引起的血压，血管尺寸和血液氧合的变化之间存在明显的相关性。
The in vivo hemodynamic impact of sodium nitroprusside (SNP), a widely used antihypertensive agent, has not been well studied. Here, we applied functional optical-resolution photoacoustic microscopy (OR-PAM) to study the hemodynamic responses to SNP in mice in vivo. As expected, after the application of SNP, the systemic blood pressure was reduced by 53%. The OR-PAM results show that SNP induced an arterial vasodilation of 24% and 23% in the brain and skin, respectively. A weaker venous vasodilation of 9% and 5% was also observed in the brain and skin, respectively. The results show two different types of blood oxygenation response. In mice with decreased blood oxygenation, the arterial and venous oxygenation were respectively reduced by 6% and 13% in the brain, as well as by 7% and 18% in the skin. In mice with increased blood oxygenation, arterial and venous oxygenation were raised by 4% and 22% in the brain, as well as by 1% and 9% in the skin. We observed venous change clearly lagged the arterial change in the skin, but not in the brain. Our results collectively show a correlation among SNP induced changes in systemic blood pressure, vessel size, and blood oxygenation. Functional photoacoustic microscopy was applied to study the hemodynamic response to sodium nitroprusside (SNP) in mice in vivo. SNP induced arterial and venous vasodilation in brain and ear. The majority of animals experienced a decrease in blood oxygenation, while the others experienced an increase. We observed a clear correlation among SNP-induced change in blood pressure, vessel size and blood oxygenation
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影响因子：
4.6
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通讯作者：
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