Comparative analysis of rodent and small mammal viromes to better understand the wildlife origin of emerging infectious diseases.
Comparative analysis of rodent and small mammal viromes to better understand the wildlife origin of emerging infectious diseases.
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啮齿动物和小型哺乳动物病毒组的比较分析，以更好地了解新发传染病的野生动物起源
DOI：
10.1186/s40168-018-0554-9
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发表时间：
2018-10-03
期刊：
影响因子：
15.5
通讯作者：
Jin Q
中科院分区：
文献类型：
--
作者：
Wu Z;Lu L;Du J;Yang L;Ren X;Liu B;Jiang J;Yang J;Dong J;Sun L;Zhu Y;Li Y;Zheng D;Zhang C;Su H;Zheng Y;Zhou H;Zhu G;Li H;Chmura A;Yang F;Daszak P;Wang J;Liu Q;Jin Q
啮齿动物约占所有哺乳动物物种的43%，分布广泛，是多种人畜共患病病毒的天然宿主，包括汉坦病毒、拉萨病毒和壁虱传播的脑炎病毒。因此，分析啮齿动物携带的病毒多样性有助于预测和降低未来人畜共患病毒病的风险。结果我们使用下一代测序元基因组分析方法对啮齿动物以及啮齿目、兔形目和中国目其他小动物中的一系列哺乳动物病毒家族进行了调查。我们对来自20个省份的3055只小动物进行了采样，然后概述了这些个体体内的哺乳动物病毒谱，以及病毒谱中新型啮齿动物和地鼠病毒的基本生态和遗传特征。进一步的分析表明，宿主分类在决定病毒多样性方面起主要作用，地理位置起次要作用。许多病毒是首次报道的，具有不同的进化谱系，并发现了与已知人类或动物病原体有关的病毒。病毒与宿主的系统树比较表明，在病毒的进化史上，宿主转移在许多不同的物种中普遍发生。结论这些结果扩大了我们对中国啮齿动物和食虫动物病毒的理解，表明在亚洲这些物种中存在着高度多样性的病毒。这些发现与我们之前的BAT病毒数据相结合，极大地增加了我们对新兴疾病热点地区人口稠密国家野生动物中病毒群落的了解。
BackgroundRodents represent around 43% of all mammalian species, are widely distributed, and are the natural reservoirs of a diverse group of zoonotic viruses, including hantaviruses, Lassa viruses, and tick-borne encephalitis viruses. Thus, analyzing the viral diversity harbored by rodents could assist efforts to predict and reduce the risk of future emergence of zoonotic viral diseases.ResultsWe used next-generation sequencing metagenomic analysis to survey for a range of mammalian viral families in rodents and other small animals of the ordersRodentia,Lagomorpha, andSoricomorphain China. We sampled 3,055 small animals from 20 provinces and then outlined the spectra of mammalian viruses within these individuals and the basic ecological and genetic characteristics of novel rodent and shrew viruses among the viral spectra. Further analysis revealed that host taxonomy plays a primary role and geographical location plays a secondary role in determining viral diversity. Many viruses were reported for the first time with distinct evolutionary lineages, and viruses related to known human or animal pathogens were identified. Phylogram comparison between viruses and hosts indicated that host shifts commonly happened in many different species during viral evolutionary history.ConclusionsThese results expand our understanding of the viromes of rodents and insectivores in China and suggest that there is high diversity of viruses awaiting discovery in these species in Asia. These findings, combined with our previous bat virome data, greatly increase our knowledge of the viral community in wildlife in a densely populated country in an emerging disease hotspot.
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影响因子：
11.8
作者：
Ishii A;Thomas Y;Moonga L;Nakamura I;Ohnuma A;Hang'ombe B;Takada A;Mweene A;Sawa H
通讯作者：
Sawa H
蝙蝠、食虫动物和啮齿动物携带的汉坦病毒的系统发育和起源
影响因子：
6.7
作者：
Guo WP;Lin XD;Wang W;Tian JH;Cong ML;Zhang HL;Wang MR;Zhou RH;Wang JB;Li MH;Xu J;Holmes EC;Zhang YZ
通讯作者：
Zhang YZ
影响因子：
5
作者：
Hemmi, Silvio;Vidovszky, Marton Z.;Harrach, Balazs
通讯作者：
Harrach, Balazs
影响因子：
--
作者：
Ganesh, Balasubramanian;Masachessi, Gisela;Mladenova, Zornitsa
通讯作者：
Mladenova, Zornitsa
DOI：
10.1016/j.jgg.2017.04.004
发表时间：
2017-05-20
期刊：
Journal of genetics and genomics = Yi chuan xue bao
影响因子：
--
作者：
Chen L;Liu B;Wu Z;Jin Q;Yang J
通讯作者：
Yang J