Human lymph node degeneration in the thoracic region: A morphometric and immunohistochemical analysis using surgically obtained specimens.
Human lymph node degeneration in the thoracic region: A morphometric and immunohistochemical analysis using surgically obtained specimens.
复制标题
DOI：
10.3389/fphys.2022.990801
复制
发表时间：
2022
影响因子：
4
通讯作者：
Sato M
中科院分区：
文献类型：
--
作者：
Jin ZW;Aoki M;Ueda K;Kamimura G;Takeda-Harada A;Murakami G;Sato M
78例患者，年龄49-82岁，无肿瘤转移，539例纵隔及肺内淋巴结切除。髓窦透明化见于36.2%的肝门淋巴结和38.5%的叶间淋巴结。早期和较小的病变为嗜酸性粒细胞和因子VIII阳性，而晚期和较大的病变包含大量胶原纤维束，少数细长细胞平滑肌肌动蛋白（SMA）和因子VIII阳性，以及炭疽巨噬细胞。4.3%的肝门淋巴结可见囊下窦透明化，在表面皮层和增厚的囊间可见厚的纤维层（超过0.2 mm）。纤维层含有sma阳性的细长细胞，而增厚的被膜含有弹性蛋白和因子VIII阳性的纤维。这些透明病变分别占肺门淋巴结和下气管旁淋巴结截面积的3.6%和0.8%。早期和小皮质变性区被SMA和vimentin阳性纤维包围，不含淋巴细胞和巨噬细胞，但含有丰富的小基质细胞。银染色提示晚期皮质变性由胶原原纤维组成，而非i型。47.8%的肝门淋巴结可见脂肪组织，常延伸至髓窦组织并取代髓窦组织。脂肪变性区髓窦的岛状残余含有多种SMA、弹性蛋白、因子VIII和/或CD34阳性的基质细胞。然而，这些退化形态与年龄或吸烟指数无关。目前的皮质变性通常是在透明化之后发生的，但两者也可能是独立发生的。
Lymph node degeneration was examined in 539 mediastinal and intrapulmonary nodes removed from 78 patients, aged 49–82 years, without cancer metastasis. Medullary sinus hyalinization observed in 36.2% of the hilar and 38.5% of the interlobar nodes. Early and smaller lesions were eosinophilic and factor VIII-positive, whereas advanced and large lesions contained a bulky mass of collagenous fiber bundles with few slender cells positive for smooth muscle actin (SMA) and factor VIII, as well as anthracotic macrophages. Subcapsular sinus hyalinization, observed in 4.3% of hilar nodes, was detected as a thick fibrous layer (over 0.2 mm) between the surface cortex and the thickened capsule. The fibrous layer contained SMA-positive slender cells, whereas the thickened capsule contained fibers positive for elastin and factor VIII. These hyalinization lesions occupied 3.6% and 0.8% of the sectional areas of hilar and lower paratracheal nodes, respectively. Areas of early and small cortical degeneration, surrounded by fibers positive for SMA and vimentin, did not contain lymphocytes and macrophages, but contained abundant small stromal cells. Silver staining suggested that advanced cortical degeneration was composed of collagen fibrils other than type I. Fatty tissues, seen in 47.8% of hilar nodes, often extended into and replaced medullary sinus tissue. Island-like remnants of medullary sinuses in areas of fatty degeneration contained various stromal cells positive for SMA, elastin, factor VIII and/or CD34. These degenerative morphologies, however, did not correlate with either age or smoking index. The present cortical degeneration usually seemed to follow hyalinization, but both were likely to occur independently.
登录
查看更多内容
影响因子：
7.3
作者：
Elewa YHA;Ichii O;Takada K;Nakamura T;Masum MA;Kon Y
通讯作者：
Kon Y
影响因子：
3.5
作者：
Yu, Hongbo;Gibson, Joanna A.;Hornick, Jason L.
通讯作者：
Hornick, Jason L.
影响因子：
2
作者：
Horie, K;Chen, D;Hoshi, H
通讯作者：
Hoshi, H
影响因子：
0.7
作者：
Erofeeva, L. M.;Mnikhovich, M. V.
通讯作者：
Mnikhovich, M. V.
影响因子：
2
作者：
Taniguchi, I;Murakami, G;Kohama, G
通讯作者：
Kohama, G