Endothelin-dependent vasoconstriction in human uterine artery: application to preeclampsia.
Endothelin-dependent vasoconstriction in human uterine artery: application to preeclampsia.
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DOI：
10.1371/journal.pone.0016540
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发表时间：
2011-01-26
期刊：
影响因子：
3.7
通讯作者：
Virsolvy A
中科院分区：
文献类型：
--
作者：
Dechanet C;Fort A;Barbero-Camps E;Dechaud H;Richard S;Virsolvy A
减少子宫胎盘灌注，先兆子痫的起始事件，与增强内皮素-1（ET-1）的生产，饲料子宫动脉的血管收缩。子痫前期的治疗是否能有效抑制ET-1诱导的胎盘收缩并逆转胎盘缺血是本研究要解决的问题。我们研究了用于先兆子痫的降压药和ET受体拮抗剂对人子宫动脉对ET-1的收缩反应的影响。对子宫切除术后获得的人子宫动脉样品进行离体实验。我们研究了血管收缩剂ET-1引起的动脉环等长张力的变化，并评估了各种血管扩张剂和ET-受体拮抗剂对这种反应的影响。在抗高血压药物中，只有二氢吡啶类药物能有效地阻断和逆转ET-1的收缩反应。其效率，独立的ET-1的浓度，只是部分的。肼苯哒嗪、α-甲基多巴和拉贝洛尔对ET-1引起的子宫动脉收缩反应无影响。ET受体拮抗剂BQ-123和BQ-788轻微降低了对ET-1的反应幅度。这两种拮抗剂的组合是更有效的，但它是不可能逆转的最大ET-1诱导的收缩与拮抗剂单独使用或组合。目前用于先兆子痫的药理学药物不能逆转ET-1诱导的收缩。只有二氢吡啶类药物可以部分地松弛先前与ET-1一起收缩的子宫动脉，这可能为改善胎盘灌注提供了有趣的前景。
Reduced uteroplacental perfusion, the initiating event in preeclampsia, is associated with enhanced endothelin-1 (ET-1) production which feeds the vasoconstriction of uterine artery. Whether the treatments of preeclampsia were effective on ET-1 induced contraction and could reverse placental ischemia is the question addressed in this study. We investigated the effect of antihypertensive drugs used in preeclampsia and of ET receptor antagonists on the contractile response to ET-1 on human uterine arteries. Experiments were performed, ex vivo, on human uterine artery samples obtained after hysterectomy. We studied variations in isometric tension of arterial rings in response to the vasoconstrictor ET-1 and evaluated the effects of various vasodilators and ET-receptor antagonists on this response. Among antihypertensive drugs, only dihydropyridines were effective in blocking and reversing the ET-1 contractile response. Their efficiency, independent of the concentration of ET-1, was only partial. Hydralazine, alpha-methyldopa and labetalol had no effect on ET-1 induced contraction which is mediated by both ETA and ETB receptors in uterine artery. ET receptors antagonists, BQ-123 and BQ-788, slightly reduced the amplitude of the response to ET-1. Combination of both antagonists was more efficient, but it was not possible to reverse the maximal ET-1-induced contraction with antagonists used alone or in combination. Pharmacological drugs currently used in the context of preeclampsia, do not reverse ET-1 induced contraction. Only dihydropyridines, which partially relax uterine artery previously contracted with ET-1, might offer interesting perspectives to improve placental perfusion.
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DOI：
10.1016/s0002-9378(11)91582-8
发表时间：
1992-09-01
影响因子：
9.8
作者：
BODELSSON, G;SJOBERG, NO;STJERNQUIST, M
通讯作者：
STJERNQUIST, M
影响因子：
3.2
作者：
KUBLICKIENE, KR;WOLFF, K;NISELL, H
通讯作者：
NISELL, H
DOI：
10.1111/j.1471-0528.1982.tb04719.x
发表时间：
1982-01-01
期刊：
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
影响因子：
--
作者：
LUNNELL, NO;NYLUND, L;SARBY, B
通讯作者：
SARBY, B
DOI：
10.1016/s0002-9378(12)90905-9
发表时间：
1993-01-01
影响因子：
9.8
作者：
MONTAN, S;ANANDAKUMAR, C;RATNAM, SS
通讯作者：
RATNAM, SS
影响因子：
4.1
作者：
Goldman-Wohl, D;Yagel, S
通讯作者：
Yagel, S