Auditory Deficits in Audiovisual Speech Perception in Adult Asperger’s Syndrome: fMRI Study
Auditory Deficits in Audiovisual Speech Perception in Adult Asperger’s Syndrome: fMRI Study
复制标题
成人阿斯伯格综合症视听言语感知的听觉缺陷：功能磁共振成像研究
作者：
Fabian;L. Hundertmark;Mandy Roy;Michael J. Zerr;C. Sinke;Daniel Wiswede;M. Walter;T. Münte;G. Szycik
视听（AV）整合缺陷被认为是阿斯伯格综合症（AS）言语感知困难的根源。目前尚不清楚 AV 缺陷是否与单感觉处理水平或联合多感觉处理水平的感觉处理改变有关。对 16 名患有 AS 的成年受试者和 16 名年龄、性别和言语智商相匹配的健康对照者 (HC) 进行了功能性磁共振成像 (MRI)，因为他们接触了双音节 AV 一致和 AV 不一致的名词。使用简单的语义分类任务来确保受试者对刺激的注意力。与 AV 一致性没有相互作用的 AS 受试者相比，HC 受试者的左听觉皮层 (BA41) 显示出更强的激活。这表明单峰低级区域听觉处理的改变是 AS 中 AV 语音感知缺陷的基础。这是否表明注意力分配存在困难还有待证明。
Audiovisual (AV) integration deficits have been proposed to underlie difficulties in speech perception in Asperger’s syndrome (AS). It is not known, if the AV deficits are related to alterations in sensory processing at the level of unisensory processing or at levels of conjoint multisensory processing. Functional Magnetic-resonance images (MRI) was performed in 16 adult subjects with AS and 16 healthy controls (HC) matched for age, gender, and verbal IQ as they were exposed to disyllabic AV congruent and AV incongruent nouns. A simple semantic categorization task was used to ensure subjects’ attention to the stimuli. The left auditory cortex (BA41) showed stronger activation in HC than in subjects with AS with no interaction regarding AV congruency. This suggests that alterations in auditory processing in unimodal low-level areas underlie AV speech perception deficits in AS. Whether this is signaling a difficulty in the deployment of attention remains to be demonstrated.
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