Respiratory viruses from hospitalized children with severe pneumonia in the Philippines.
Respiratory viruses from hospitalized children with severe pneumonia in the Philippines.
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DOI：
10.1186/1471-2334-12-267
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发表时间：
2012-10-23
影响因子：
3.7
通讯作者：
Oshitani H
中科院分区：
文献类型：
--
作者：
Suzuki A;Lupisan S;Furuse Y;Fuji N;Saito M;Tamaki R;Galang H;Sombrero L;Mondoy M;Aniceto R;Olveda R;Oshitani H
肺炎仍然是发展中国家儿童死亡的主要原因。严重肺炎中的病毒仍不明确。该研究于2008年5月至2009年5月在菲律宾塔克洛班市的东米沙鄢地区医疗中心进行。本研究入组了8天至13岁因重度肺炎入住儿科的患者。入院后，使用鼻咽拭子和血培养进行聚合酶链反应，分别检测呼吸道病毒和细菌。在入组的819例患者中，501例（61.2%）至少检测到一种病毒。此外，423例对单一病毒呈阳性反应，31例在血培养样本中检出细菌。最常检出的病毒是人鼻病毒（n = 189），包括A型（n = 103）、B型（n = 17）和C型（n = 69），以及呼吸道合胞病毒（RSV）（n = 165）。新的病毒，如人类偏肺病毒，人类冠状病毒NL 63，人类博卡病毒，和人类多瘤病毒WU和KI也被检测到。有70例死亡，其中35例（50%）检测到一种或多种病毒。仅甲型流感病毒阳性（OR = 4.3，95% CI = 1.3-14.6）与致死性结局显著相关。从血培养中还分离出洋葱伯克霍尔德菌群（n = 9）、肺炎链球菌（n = 4）、金黄色葡萄球菌（n = 4）、流感嗜血杆菌（n = 1）和沙门氏菌C1（n = 1）。在菲律宾，病毒通常在患有严重肺炎的儿童中检测到。因此，在制定更有效的战略以减少发展中国家儿童肺炎相关死亡的同时，应考虑病毒病因。
Pneumonia remains a leading cause of child death in developing countries. The viruses in severe pneumonia remain poorly defined. The study was conducted at the Eastern Visayas Regional Medical Center in Tacloban City, Philippines from May 2008 to May 2009. Patients aged 8 days to 13 years old who were admitted to the Department of Pediatrics with severe pneumonia were enrolled for the study. Upon admission, polymerase chain reaction was performed using nasopharyngeal swabs and blood cultures to detect respiratory viruses and bacteria, respectively. Among the 819 patients enrolled, at least one virus was detected in 501 cases (61.2%). In addition, 423 cases were positive for a single virus while bacteria were detected in the blood culture sample of 31 cases. The most commonly detected viruses were human rhinoviruses (n = 189), including types A (n = 103), B (n = 17), and C (n = 69), and respiratory syncytial virus (RSV) (n = 165). Novel viruses such as human metapneumovirus, human coronavirus NL63, human bocavirus, and human polyomaviruses WU and KI were also detected. There were 70 deaths, and one or more viruses were detected in 35 (50%) of these cases. Positivity only for influenza A virus (OR = 4.3, 95% CI = 1.3-14.6) was significantly associated with fatal outcome. From the blood culture, Burkholderia cepacia group (n = 9), Streptococcus pneumoniae (n = 4), Staphylococcus aureus (n = 4), Haemophilus influenzae (n = 1), and Salmonella C1 (n = 1) were also isolated. Viruses were commonly detected in children with severe pneumonia in the Philippines. Hence, viral etiologies should be considered while developing better effective strategies to reduce child pneumonia-related deaths in developing countries.
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DOI：
10.4269/ajtmh.2000.62.341
发表时间：
2000-03-01
影响因子：
3.3
作者：
Lupisan, SP;Herva, E;Ruutu, P
通讯作者：
Ruutu, P
影响因子：
3.1
作者：
Bellau-Pujol S;Vabret A;Legrand L;Dina J;Gouarin S;Petitjean-Lecherbonnier J;Pozzetto B;Ginevra C;Freymuth F
通讯作者：
Freymuth F
影响因子：
9.4
作者：
Casas, I;Avellon, A;Palacios, G
通讯作者：
Palacios, G
DOI：
10.1073/pnas.0504666102
发表时间：
2005-09-06
影响因子：
11.1
作者：
Allander, T;Tammi, MT;Andersson, B
通讯作者：
Andersson, B
影响因子：
6.4
作者：
Lau, Susanna K. P.;Yip, Cyril C. Y.;Yuen, Kwok-Yung
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Yuen, Kwok-Yung