Leukocyte telomere length is associated with cognitive performance in healthy women.
Leukocyte telomere length is associated with cognitive performance in healthy women.
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DOI：
10.1016/j.neurobiolaging.2008.07.012
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发表时间：
2010-06
影响因子：
4.2
通讯作者：
Cherkas, L. F.
中科院分区：
文献类型：
--
作者：
Valdes, A. M.;Deary, I. J.;Gardner, J.;Kimura, M.;Lu, X.;Spector, T. D.;Aviv, A.;Cherkas, L. F.
与肥胖相关的认知能力下降始于中年，并随着年龄的增长而持续。白细胞端粒长度（LTL）随着年龄的增长而缩短，炎症和氧化应激增强了这一过程。较短的LTL与痴呆症有关。在一项横断面研究中，使用剑桥神经心理测试自动组合（CANTAB）中的6项测试，对TwinsUK队列中382名未诊断为任何形式的痴呆或认知障碍的女性（平均年龄50.6岁，范围19-78岁）进行了认知功能和LTL之间的关系进行了研究。在调整年龄和估计先前的智力能力后，我们观察到LTL与情景记忆和相关学习（PAL，p=0.032），非语言模式识别记忆（DMS，p=0.007）和工作记忆容量（SSP，p=0.003）的显著相关性。在LTL不一致的双胞胎中，端粒较长的双胞胎的DMS（p<0.05）和SSP（p<0.013）评分也显著优于端粒较短的双胞胎。这两个评分和LTL之间的相关性在中位平均年龄以上和中位年龄以下的女性中均具有显著性，并且在对潜在混杂因素进行统计学调整后仍具有显著性。白细胞端粒长度与认知表现的一个子集的措施，这表明它可能是一个生物标志物的认知老化的女性痴呆症发作前。
Age-related cognitive decline begins in mid-life and continues with advancing age. Leukocyte telomere length (LTL) shortens with age, and inflammation and oxidative stress enhance this process. Shorter LTL is associated with dementia. The relationship between cognitive function and LTL was investigated in a cross-sectional study of 382 women (mean age 50.6 years, range 19–78), not diagnosed with any form of dementia or cognitive impairment, from the TwinsUK cohort using 6 tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB). After adjusting for age and estimated prior intellectual ability, we observed significant correlations of LTL with episodic memory and associated learning (PAL, p=0.032), recognition memory for non-verbal patterns (DMS, p=0.007), and working memory capacity (SSP, p=0.003). In pairs of twins discordant for LTL the twin with longer telomeres also had significantly better DMS (p<0.05) and SSP (p<0.013) scores than their co-twin with shorter telomeres. The correlations between these two scores and LTLwas significant both in women over the median mean age and in those below the median age, and remained significant after statistical adjustment for potential confounders. Leukocyte telomere length correlates with a subset of measures of cognitive performance, suggesting that it might be a biomarker of cognitive aging in women before the onset of dementia.
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影响因子：
9.9
作者：
McGurn, B;Starr, JM;Deary, IJ
通讯作者：
Deary, IJ
影响因子：
8.3
作者：
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影响因子：
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作者：
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DOI：
10.1093/gerona/61.8.871
发表时间：
2006-08-01
影响因子：
5.1
作者：
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通讯作者：
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影响因子：
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作者：
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