Distinct Thalamic Reticular Cell Types Differentially Modulate Normal and Pathological Cortical Rhythms.
Distinct Thalamic Reticular Cell Types Differentially Modulate Normal and Pathological Cortical Rhythms.
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DOI：
10.1016/j.celrep.2017.05.044
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发表时间：
2017-06-06
期刊：
影响因子：
8.8
通讯作者：
Paz JT
中科院分区：
文献类型：
--
作者：
Clemente-Perez A;Makinson SR;Higashikubo B;Brovarney S;Cho FS;Urry A;Holden SS;Wimer M;Dávid C;Fenno LE;Acsády L;Deisseroth K;Paz JT
综合脑功能依赖于广泛分布的、有节奏协调的计算。通过与大脑皮层和大多数感官的长期联系，丘脑协调了认知和感官信息的流动。在这一过程中必不可少的是，丘脑网状核（nRT）通过其广泛的抑制作用将不同的信息流传送到其他丘脑核；然而，我们缺乏对nRT中不同抑制神经元亚群如何作为看门人的理解。基于小白蛋白（PV）和生长抑素（SOM）的表达，我们分离了啮齿动物nRT中神经元的连通性、生理和回路功能，并验证了这些群体在人类nRT中的存在。我们发现PV细胞而不是SOM细胞具有节律性，并且PV和SOM神经元连接并调节不同的丘脑皮层回路。值得注意的是，PV而不是SOM神经元调节体感觉行为并扰乱癫痫发作。这些结果为nRT如何控制输入信息以调节全脑节律提供了一个概念性框架。Clemente等人在细胞、电路和行为水平上解构了网状丘脑（nRT）。他们发现nRT中表达小白蛋白和生长抑素的神经元具有不同的细胞和电路特性，沿着主要不重叠的神经元通路分离，并差异调节丘脑皮层节律发生、体感行为和全局性癫痫发作。
Integrative brain functions depend on widely distributed, rhythmically coordinated computations. Through its long-ranging connections with cortex and most senses, the thalamus orchestrates the flow of cognitive and sensory information. Essential in this process, the nucleus reticularis thalami (nRT) gates different information streams through its extensive inhibition onto other thalamic nuclei; however, we lack an understanding of how different inhibitory neuron subpopulations in nRT function as gatekeepers. We dissociated the connectivity, physiology, and circuit functions of neurons within rodent nRT, based on parvalbumin (PV) and somatostatin (SOM) expression, and validated the existence of such populations in human nRT. We found that PV but not SOM cells are rhythmogenic, and that PV and SOM neurons are connected to and modulate distinct thalamocortical circuits. Notably, PV but not SOM neurons modulate somatosensory behavior and disrupt seizures. These results provide a conceptual framework for how nRT may gate incoming information to modulate brain-wide rhythms. Clemente et al. deconstruct the reticular thalamus (nRT) at the cellular, circuit, and behavioral levels. They find that parvalbumin- and somatostatin-expressing neurons in nRT have distinct cellular and circuit properties, segregate along predominantly non-overlapping neuronal pathways, and differentially modulate thalamocortical rhythmogenesis, somatosensory behavior, and generalized seizures.
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