Anxiety in transition: Neuroendocrine mechanisms supporting the development of anxiety pathology in adolescence and young adulthood.
Anxiety in transition: Neuroendocrine mechanisms supporting the development of anxiety pathology in adolescence and young adulthood.
复制标题
DOI：
10.1016/j.yfrne.2019.100791
复制
发表时间：
2019-10
影响因子：
7.4
通讯作者：
Matyi MA
中科院分区：
文献类型：
--
作者：
Spielberg JM;Schwarz JM;Matyi MA
青春期标志着一个关键的发展窗口，在此期间，情绪失调增加，沿着焦虑和其他与情感有关的病理的发病风险。虽然情绪失调和相关的病理正常下降过渡到成年期，这并不发生在一个相当大的少数人。最后，焦虑的性别差异出现在青春期，女性的风险相对于男性增加了2倍。不幸的是，在青春期引起这些变化的机制的神经生物学模型尚未提出。在目前的工作中，我们首先提供相关文献的简要回顾。接下来，我们概述了一个双机制模型，重点是（i）青春期睾酮对关键情绪调节回路的影响（即，眶额皮质-杏仁核耦合）和（ii）连接这种回路的纤维束的髓鞘形成（即，钩束）。所提出的模型提供了一套具体的、可检验的假设，有望刺激急需的跨学科研究。
Adolescence marks a key developmental window during which emotion dysregulation increases, along with risk for the onset of anxiety and other affect-related pathologies. Although emotion dysregulation and related pathologies normatively decline during the transition into adulthood, this does not occur for a sizable minority of individuals. Finally, sex differences in anxiety emerge during adolescence, with females developing a 2-fold increase in risk relative to males. Unfortunately, a neurobiological model of the mechanisms that cause these changes during adolescence has yet to be proposed. In the present work, we first provide brief reviews of relevant literature. Next, we outline a dual-mechanism model focused on (i) the influence of pubertal testosterone on key emotion-regulation circuitry (i.e., orbitofrontal cortex-amygdala coupling) and (ii) myelination of the fiber bundles connecting such circuitry (i.e., uncinate fasciculus). The proposed model offers a set of specific, testable hypotheses that will hopefully spur much needed cross-disciplinary research.
登录
查看更多内容
影响因子：
3.5
作者：
Beltz, Adriene M.;Berenbaum, Sheri A.
通讯作者：
Berenbaum, Sheri A.
影响因子：
4.6
作者：
Best JR;Miller PH
通讯作者：
Miller PH
影响因子：
25
作者：
Ahmed, Eman I.;Zehr, Julia L.;Schulz, Kalynn M.;Lorenz, Betty H.;DonCarlos, Lydia L.;Sisk, Cheryl L.
通讯作者：
Sisk, Cheryl L.
影响因子：
12.8
作者：
Cisler JM;Koster EH
通讯作者：
Koster EH
影响因子：
2.3
作者：
CANALS, J;MARTIHENNEBERG, C;DOMENECH, E
通讯作者：
DOMENECH, E