Canine tonsillar neoplasia and tonsillar metastasis from various primary neoplasms.
Canine tonsillar neoplasia and tonsillar metastasis from various primary neoplasms.
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DOI：
10.1111/vco.12604
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发表时间：
2020-12
影响因子：
2.1
通讯作者：
Seguin B
中科院分区：
文献类型：
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作者：
Mickelson MA;Regan D;Randall EK;Worley D;Seguin B
扁桃体远处原发肿瘤转移尚未在犬中描述，在人类中的报告也很罕见。本研究的目的是确定是否发生肿瘤转移到犬腭扁桃体和评估是否传入淋巴管引流到腭扁桃体通过颅骨间接计算机断层扫描淋巴管造影（ICTL）。对诊断实验室扁桃体组织病理学提交资料进行回顾性审查。ICTL研究（n=53）由一名放射科医生进行回顾性审查。在882个扁桃体组织病理学样本中，492个（56%）被认为是肿瘤，其中8%是良性的。扁桃体原发性恶性肿瘤中，鳞状细胞癌（55%）、淋巴瘤（17%）和黑色素瘤（12%）最为常见。扁桃体转移41例，组织病理学评价显示黑色素瘤（25），癌（10），血管肉瘤（2）和纤维肉瘤，恶性组织细胞增生症，基底细胞瘤，未分化肉瘤各1例。确定了53例扁桃体黑色素瘤病例，其中25例为已知远处原发肿瘤的转移，28例仅为扁桃体，其中9例伴有淋巴结转移。没有ICTL病例有淋巴造影剂引流到腭扁桃体。腭扁桃体是一个重要的网站转移的各种原发性肿瘤类型从许多地方。ICTL未显示淋巴细胞引流至腭扁桃体，这高度支持血行性扁桃体转移途径。扁桃体转移可能比以前认为的更常见。建议对所有口腔肿瘤和黑色素瘤病例进行彻底的口腔检查，包括扁桃体。
Tonsillar metastasis from distant primary tumors has not been described in dogs, and reports are rare in humans. The aims of this study were to determine whether tumor metastasis occurs to the canine palatine tonsils and evaluate whether afferent lymphatics drain to the palatine tonsils via skull indirect computed tomography lymphangiography (ICTL). Retrospective review of the diagnostic laboratory tonsillar histopathology submissions was performed. ICTL studies (n=53) were retrospectively reviewed by a single radiologist. Of 882 total tonsil histopathology samples, 492 (56%) were considered neoplastic, with 8% of them benign. Of the primary malignant neoplasms of the tonsil, squamous cell carcinoma (55%), lymphoma (17%), and melanoma (12%) were most common. Tonsillar metastasis was confirmed in 41 cases; histopathologic evaluation revealed melanoma (25), carcinoma (10), hemangiosarcoma (2) and one each of fibrosarcoma, malignant histiocytosis, basal cell tumor, and undifferentiated sarcoma. Fifty-three tonsillar melanoma cases were identified, of which 25 represented metastasis from a known distant primary tumor and 28 were solely tonsillar, with 9 of these cases having concurrent lymph node metastasis. No ICTL cases had lymphatic contrast drainage to the palatine tonsil. The palatine tonsil is an important site of metastasis for a variety of primary tumor types from many locations. ICTL did not reveal lymphatics draining to the palatine tonsil, which is highly supportive of hematogenous route of metastasis to the tonsil. Tonsillar metastasis may be more common than previously thought. It is recommended to perform a thorough oral examination, including the tonsils, for all oral tumors and melanoma cases.
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影响因子：
1.7
作者：
Rossi, Federica;Korner, Maximilian;Bley, Carla Rohrer
通讯作者：
Bley, Carla Rohrer
影响因子：
4
作者：
D'Antonio, Chiara;Lombardini, Alberto;Marchetti, Paolo
通讯作者：
Marchetti, Paolo
影响因子：
1.4
作者：
Kelley, Philip M.;Tempero, Richard M.
通讯作者：
Tempero, Richard M.
影响因子：
2.4
作者：
Ramos-Vara, J. A.;Miller, M. A.
通讯作者：
Miller, M. A.
影响因子：
--
作者：
Casteleyn C;Breugelmans S;Simoens P;Van den Broeck W
通讯作者：
Van den Broeck W