Evolution of neuropeptide signalling systems.
Evolution of neuropeptide signalling systems.
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DOI：
10.1242/jeb.151092
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发表时间：
2018-02-09
期刊：
影响因子：
--
通讯作者：
Larhammar D
中科院分区：
文献类型：
--
作者：
Elphick MR;Mirabeau O;Larhammar D
神经肽是一类不同的神经信号分子，调节动物的生理过程和行为。然而，确定在一系列门中发现的神经肽的异质组合的关系和进化起源对比较生理学家来说是一个巨大的挑战。在这里，我们回顾了最近通过对基因组/转录组序列数据的比较分析和神经肽受体的去变形而获得的对神经肽信号的进化的革命性见解。至少有30个神经肽信号系统的进化起源被追溯到原口和后口的共同祖先。此外，两轮基因组复制导致了脊椎动物谱系中神经肽信号系统的扩展，使新的功能化和/或亚功能化成为可能，但谱系特有的基因丢失和/或额外的基因或基因组复制在邻近神经肽信号系统的系统发育分布中产生了复杂的模式。我们正在进入神经肽研究的新时代，在这个时代，比较直系和旁系神经肽在广泛的门类中的生理作用已经成为可能。此外，重建动物界神经肽功能进化的雄心勃勃的任务现在代表着对未来的切实挑战。摘要：回顾了我们对神经肽信号系统进化的知识的革命性进展，这些系统是由比较基因组学和神经肽受体去形态化实现的。
Neuropeptides are a diverse class of neuronal signalling molecules that regulate physiological processes and behaviour in animals. However, determining the relationships and evolutionary origins of the heterogeneous assemblage of neuropeptides identified in a range of phyla has presented a huge challenge for comparative physiologists. Here, we review revolutionary insights into the evolution of neuropeptide signalling that have been obtained recently through comparative analysis of genome/transcriptome sequence data and by ‘deorphanisation’ of neuropeptide receptors. The evolutionary origins of at least 30 neuropeptide signalling systems have been traced to the common ancestor of protostomes and deuterostomes. Furthermore, two rounds of genome duplication gave rise to an expanded repertoire of neuropeptide signalling systems in the vertebrate lineage, enabling neofunctionalisation and/or subfunctionalisation, but with lineage-specific gene loss and/or additional gene or genome duplications generating complex patterns in the phylogenetic distribution of paralogous neuropeptide signalling systems. We are entering a new era in neuropeptide research where it has become feasible to compare the physiological roles of orthologous and paralogous neuropeptides in a wide range of phyla. Moreover, the ambitious mission to reconstruct the evolution of neuropeptide function in the animal kingdom now represents a tangible challenge for the future. Summary: A review of the revolutionary advances in our knowledge of the evolution of neuropeptide signalling systems that have been enabled by comparative genomics and neuropeptide receptor deorphanisation.
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影响因子：
16.6
作者：
Berthelot, Camille;Brunet, Frederic;Chalopin, Domitille;Juanchich, Amelie;Bernard, Maria;Noel, Benjamin;Bento, Pascal;Da Silva, Corinne;Labadie, Karine;Alberti, Adriana;Aury, Jean-Marc;Louis, Alexandra;Dehais, Patrice;Bardou, Philippe;Montfort, Jerome;Klopp, Christophe;Cabau, Cedric;Gaspin, Christine;Thorgaard, Gary H.;Boussaha, Mekki;Quillet, Edwige;Guyomard, Rene;Galiana, Delphine;Bobe, Julien;Volff, Jean-Nicolas;Genet, Carine;Wincker, Patrick;Jaillon, Olivier;Roest Crollius, Hugues;Guiguen, Yann
通讯作者：
Guiguen, Yann
影响因子：
6.1
作者：
BROWN, BE
通讯作者：
BROWN, BE
影响因子：
5.2
作者：
Caers J;Verlinden H;Zels S;Vandersmissen HP;Vuerinckx K;Schoofs L
通讯作者：
Schoofs L
DOI：
10.1016/s0006-291x(02)02398-7
发表时间：
2002-10-18
影响因子：
3.1
作者：
Cazzamali, G;Saxild, NPE;Grimmelikhuijzen, CJP
通讯作者：
Grimmelikhuijzen, CJP
影响因子：
1.9
作者：
Cardoso, Joao C. R.;Felix, Rute C.;Power, Deborah M.
通讯作者：
Power, Deborah M.