Long-term recording reliability of liquid crystal polymer µECoG arrays.
Long-term recording reliability of liquid crystal polymer µECoG arrays.
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DOI：
10.1088/1741-2552/aae39d
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发表时间：
2018-12
影响因子：
4
通讯作者：
Viventi J
中科院分区：
文献类型：
--
作者：
Woods V;Trumpis M;Bent B;Palopoli-Trojani K;Chiang CH;Wang C;Yu C;Insanally MN;Froemke RC;Viventi J
在广泛的皮质区域记录的微信号的临床使用在很大程度上受到植入接口的长期可靠性的限制。我们评估了新型 61 通道微皮质电图 (μECoG) 阵列在长期植入大鼠体内一年多并使用加速老化的长期可靠性。器件采用聚酰亚胺 (PI) 或液晶聚合物 (LCP) 封装，并采用商业制造工艺制造。体外失效模式和预测寿命是通过加速浸泡测试确定的。成功的设计被硬膜外植入啮齿动物听觉皮层。报告了植入一年多的基线信号水平、诱发反应和解码性能的趋势。使用 LCP 制造的器件始终比 PI 封装具有更长的体外寿命。我们的加速老化结果预测设备完整性超过 3.4 年。五个植入阵列在整个植入期间（247-435 天）表现出稳定的性能。我们的回归分析表明，阻抗仅在前 31 天的记录中预测信号质量和信息内容，而在慢性期（> 31 天）几乎没有预测价值。在慢性阶段，位点阻抗略有下降，但解码性能在统计上与阻抗不相关。我们还采用了改进的空间变化统计模型来测量对局部变化场的敏感性，这通常隐藏在标准信号功率计算中。这些发现表明，μECoG 阵列可以在体内长期应用中可靠地运行一年以上，这有助于开发高密度、临床上可行的接口。
The clinical use of microsignals recorded over broad cortical regions is largely limited by the chronic reliability of the implanted interfaces. We evaluated the chronic reliability of novel 61-channel micro-electrocorticographic (μECoG) arrays in rats chronically implanted for over one year and using accelerated aging. Devices were encapsulated with polyimide (PI) or liquid crystal polymer (LCP), and fabricated using commercial manufacturing processes. In vitro failure modes and predicted lifetimes were determined from accelerated soak testing. Successful designs were implanted epidurally over the rodent auditory cortex. Trends in baseline signal level, evoked responses and decoding performance were reported for over one year of implantation. Devices fabricated with LCP consistently had longer in vitro lifetimes than PI encapsulation. Our accelerated aging results predicted device integrity beyond 3.4 years. Five implanted arrays showed stable performance over the entire implantation period (247–435 days). Our regression analysis showed that impedance predicted signal quality and information content only in the first 31 days of recordings and had little predictive value in the chronic phase (> 31 days). In the chronic phase, site impedances slightly decreased yet decoding performance became statistically uncorrelated with impedance. We also employed an improved statistical model of spatial variation to measure sensitivity to locally varying fields, which is typically concealed in standard signal power calculations. These findings show that μECoG arrays can reliably perform in chronic applications in vivo for over one year, which facilitates the development of a high-density, clinically viable interface.
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