Physical activity, memory function, and hippocampal volume in adults with Down syndrome.
Physical activity, memory function, and hippocampal volume in adults with Down syndrome.
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DOI：
10.3389/fnint.2022.919711
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发表时间：
2022
影响因子：
3.5
通讯作者：
Hartley, Sigan L.
中科院分区：
文献类型：
--
作者：
Peven, Jamie C.;Handen, Benjamin L.;Laymon, Charles M.;Fleming, Victoria;Piro-Gambetti, Brianna;Christian, Bradley T.;Klunk, William;Cohen, Ann D.;Okonkwo, Ozioma;Hartley, Sigan L.
较高的参与中等强度的体力活动（PA）与神经型成年人更好的认知功能有关;然而，关于PA对唐氏综合征（DS）成年人认知老化的影响知之甚少。患有DS的个体有三个21号染色体拷贝，其中包括参与淀粉样前体蛋白产生的基因，导致阿尔茨海默病（AD）早期发作的风险增加。本研究的目的是了解DS成人中中度PA参与、记忆和海马体积之间的关系。患有DS的成年人参加了与阿尔茨海默氏病生物标志物联盟有关的辅助生活方式研究（ABC-DS; N = 71）。根据线索回忆测试（CRT）和Rivermead图片识别测试的表现创建样本内z分数记忆复合物。参与者佩戴腕戴式加速度计（GT9X）来测量PA。感兴趣的变量包括中度PA花费的时间的平均百分比和平均每日步数。在体动记录/认知数据收集的18个月内采集了一部分参与者（n = 54）的结构MRI数据。使用Freesurfer v5.3提取海马体积。通过控制相关协变量[年龄、体重指数、智力残疾水平、性别和颅内体积]的分层线性回归，评价中度PA参与、记忆和海马体积之间的相关性。参与者年龄为37.77岁（SD = 8.21），女性占55.6%。他们花了11.1%的时间从事中度PA（SD = 7.5%），平均每天走12，096.51步（SD = 4，315.66）。在控制相关协变量后，较高的记忆综合评分与较高的中度PA参与（β = 0.232，p = 0.027）和更多的每日步数（β = 0.209，p = 0.037）相关。在一个参与者子集中，在控制相关协变量后，PA变量与海马体积无显著相关性（所有p值≥ 0.42）。在控制相关协变量后，海马体积越大，记忆综合评分越高（β = 0.316，p = 0.017）。更多的PA参与与DS成年人更好的记忆功能有关。虽然更大的海马体积与更好的记忆表现有关，但与PA无关。更大的PA参与可能是一个有前途的生活方式行为，以保持记忆的成年人与DS。
Higher engagement in moderate-intensity physical activity (PA) is related to better cognitive functioning in neurotypical adults; however, little is known about the effect of PA on cognitive aging in adults with Down syndrome (DS). Individuals with DS have three copies of chromosome 21, which includes the gene involved in the production of the amyloid precursor protein, resulting in an increased risk for an earlier onset of Alzheimer’s disease (AD). The goal of this study was to understand the relationship between engagement in moderate PA, memory, and hippocampal volume in adults with DS. Adults with DS participated in an ancillary Lifestyle study linked to the Alzheimer’s Biomarkers Consortium for DS (ABC- DS; N = 71). A within-sample z-score memory composite was created from performance on the Cued Recall Test (CRT) and the Rivermead Picture Recognition Test. Participants wore a wrist-worn accelerometer (GT9X) to measure PA. Variables of interest included the average percentage of time spent in moderate PA and average daily steps. Structural MRI data were acquired within 18 months of actigraphy/cognitive data collection for a subset of participants (n = 54). Hippocampal volume was extracted using Freesurfer v5.3. Associations between moderate PA engagement, memory, and hippocampal volume were evaluated with hierarchical linear regressions controlling for relevant covariates [age, body mass index, intellectual disability level, sex, and intracranial volume]. Participants were 37.77 years old (SD = 8.21) and were 55.6% female. They spent 11.1% of their time engaged in moderate PA (SD = 7.5%) and took an average of 12,096.51 daily steps (SD = 4,315.66). After controlling for relevant covariates, higher memory composite score was associated with greater moderate PA engagement (β = 0.232, p = 0.027) and more daily steps (β = 0.209, p = 0.037). In a subset of participants, after controlling for relevant covariates, PA variables were not significantly associated with the hippocampal volume (all p-values ≥ 0.42). Greater hippocampal volume was associated with higher memory composite score after controlling for relevant covariates (β = 0.316, p = 0.017). More PA engagement was related to better memory function in adults with DS. While greater hippocampal volume was related to better memory performance, it was not associated with PA. Greater PA engagement may be a promising lifestyle behavior to preserve memory in adults with DS.
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影响因子：
3.6
作者：
Chen, C. -C. (J. J. );Ringenbach, S. D. R.
通讯作者：
Ringenbach, S. D. R.
DOI：
10.1097/00005768-199805000-00021
发表时间：
1998-05-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Freedson, PS;Melanson, E;Sirard, J
通讯作者：
Sirard, J
影响因子：
3.6
作者：
Carvalho A;Rea IM;Parimon T;Cusack BJ
通讯作者：
Cusack BJ
影响因子：
4.2
作者：
Fleming V;Piro-Gambetti B;Patrick A;Zammit M;Alexander A;Christian BT;Handen B;Cohen A;Klunk W;Laymon C;Ances BM;Plante DT;Okonkwo O;Hartley SL
通讯作者：
Hartley SL
影响因子：
4.2
作者：
Erickson KI;Leckie RL;Weinstein AM
通讯作者：
Weinstein AM