Defining the malaria burden in Nchelenge District, northern Zambia using the World Health Organization malaria indicators survey.
Defining the malaria burden in Nchelenge District, northern Zambia using the World Health Organization malaria indicators survey.
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DOI：
10.1186/1475-2875-13-220
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发表时间：
2014-06-05
期刊：
影响因子：
3
通讯作者：
D'Alessandro U
中科院分区：
文献类型：
--
作者：
Nambozi M;Malunga P;Mulenga M;Van Geertruyden JP;D'Alessandro U
疟疾被认为是主要的公共卫生问题之一，也是导致贫困的疾病之一。在传播稳定和相对较高的地区，孕妇及其新生儿属于较高风险群体。关于孕期青蒿素联合疗法(ACT)几种制剂的安全性和有效性的多中心试验目前正在包括赞比亚在内的四个非洲国家进行，赞比亚的研究地点在恩切伦格区。由于研究结果可能受到当地疟疾地方性的影响，因此需要对此进行描述。2012年3月至4月在恩切伦格区进行了一项横断面调查，以确定10岁儿童的感染率和感染强度。抽样单位是所有10岁的 <； 儿童都包括在调查中的家庭，使用全球定位系统编码列表上的简单随机家庭选择。从每个被招募的儿童身上采集了一份血液样本，用于确定血红蛋白浓度和确定疟疾感染情况。选择了630户家庭，对782名儿童进行了疟疾和贫血测试。疟疾感染率为30.2%(236/782)，其中恶性疟占97.9%(231/236)，疟疾占2.1%(5/236)。贫血，定义为血红蛋白浓度为11微克/分升，在51.2%(398/782)的儿童中被检测到。在赞比亚，尽管据报告疟疾负担有所下降，但疟疾高度流行的地区，如恩切伦格地区，仍然存在。这是一个边界地区，只有作出协调一致的努力，以扩大目前跨越边界的管制干预措施的复盖面，才能取得重大进展。
Malaria is considered as one of the major public health problems and among the diseases of poverty. In areas of stable and relatively high transmission, pregnant women and their newborn babies are among the higher risk groups. A multicentre trial on the safety and efficacy of several formulations of artemisinin-based combination therapy (ACT) during pregnancy is currently on-going in four African countries, including Zambia, whose study site is in Nchelenge district. As the study outcomes may be influenced by the local malaria endemicity, this needs to be characterized. A cross-sectional survey to determine the prevalence and intensity of infection among <10 years old was carried out in March-April 2012 in Nchelenge district. The sampling unit was the household where all children < 10 years of age were included in the survey using simple random household selection on a GPS coded list. A blood sample for determining haemoglobin concentration and identifying malaria infection was collected from each recruited child. Six hundred thirty households were selected and 782 children tested for malaria and anaemia. Prevalence of malaria infection was 30.2% (236/782), the large majority (97.9%, 231/236) being Plasmodium falciparum and the remaining ones (2.1%, 5/236) Plasmodium malariae. Anaemia, defined as haemoglobin concentration <11 g/dl, was detected in 51.2% (398/782) children. In Zambia, despite the reported decline in malaria burden, pockets of high malaria endemicity, such as Nchelenge district, still remain. This is a border area and significant progress can be achieved only by concerted efforts aimed at increasing coverage of current control interventions across the border.
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影响因子：
2
作者：
Ouedraogo, Hermann Z.;Zeba, Augustin;Donnen, Philippe
通讯作者：
Donnen, Philippe
DOI：
10.4269/ajtmh.2007.76.42
发表时间：
2007-01-01
影响因子：
3.3
作者：
Sharp, Brian L.;Kleinschmidt, Immo;Barreto, Averting
通讯作者：
Barreto, Averting
影响因子：
4.2
作者：
Lozoff, Betsy
通讯作者：
Lozoff, Betsy
影响因子：
3.7
作者：
Ouedraogo, Andre Lin;Bousema, Teun;Sauerwein, Robert
通讯作者：
Sauerwein, Robert
影响因子：
3.4
作者：
Warhurst, DC;Williams, JE
通讯作者：
Williams, JE