An omniphobic lubricant-infused coating produced by chemical vapor deposition of hydrophobic organosilanes attenuates clotting on catheter surfaces.
An omniphobic lubricant-infused coating produced by chemical vapor deposition of hydrophobic organosilanes attenuates clotting on catheter surfaces.
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DOI：
10.1038/s41598-017-12149-1
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发表时间：
2017-09-14
影响因子：
4.6
通讯作者：
Didar TF
中科院分区：
文献类型：
--
作者：
Badv M;Jaffer IH;Weitz JI;Didar TF
导管相关血栓形成是一个持续存在的问题。基于生物相容的液体润滑剂在疏水有机硅烷自组装单分子层上形成的全方位涂层可以减少表面的凝血。在这里，我们报告了一种高效、非侵入性和坚固的方法，在导管上涂上一种抗血栓的、全厌恶的润滑剂涂层，这种涂层是用疏水的含氟有机硅烷的化学气相沉积(CVD)法生产的。与未涂层导管相比，CVD涂层导管通过接触凝血途径显著减少血栓形成。与常用的含氟有机硅烷的液相沉积(LPD)技术相比，CVD方法效率更高，重复性更好，对导管外层聚合物的破坏较少，具有更强的抗血栓活性。因此，使用CVD方法对导管进行全方位涂层是一种简单、直接和非侵入性的方法。这种方法不仅有可能防止导管血栓形成，而且还可以防止其他接触血液的医疗设备上的血栓形成。
Catheter associated thrombosis is an ongoing problem. Omniphobic coatings based on tethering biocompatible liquid lubricants on self-assembled monolayers of hydrophobic organosilanes attenuate clotting on surfaces. Herein we report an efficient, non-invasive and robust process for coating catheters with an antithrombotic, omniphobic lubricant-infused coating produced using chemical vapor deposition (CVD) of hydrophobic fluorine-based organosilanes. Compared with uncoated catheters, CVD coated catheters significantly attenuated thrombosis via the contact pathway of coagulation. When compared with the commonly used technique of liquid phase deposition (LPD) of fluorine-based organosilanes, the CVD method was more efficient and reproducible, resulted in less disruption of the outer polymeric layer of the catheters and produced greater antithrombotic activity. Therefore, omniphobic coating of catheters using the CVD method is a simple, straightforward and non-invasive procedure. This method has the potential to not only prevent catheter thrombosis, but also to prevent thrombosis on other blood-contacting medical devices.
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影响因子：
14
作者：
Chen, H;Zhang, Z;Sheardown, H
通讯作者：
Sheardown, H
影响因子：
4.9
作者：
Jin, Zhilin;Feng, Wei;Brash, John L.
通讯作者：
Brash, John L.
影响因子：
14
作者：
Jo, S;Park, K
通讯作者：
Park, K
影响因子：
15.6
作者：
Mao, C;Qiu, YZ;Lin, SC
通讯作者：
Lin, SC
DOI：
10.1163/156856202320253910
发表时间：
2002-01-01
影响因子：
3.6
作者：
Shen, MC;Martinson, L;Horbett, TA
通讯作者：
Horbett, TA