The Chromosomal Courtship Dance-homolog pairing in early meiosis.
The Chromosomal Courtship Dance-homolog pairing in early meiosis.
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DOI：
10.1016/j.ceb.2013.12.004
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发表时间：
2014-03
影响因子：
7.5
通讯作者：
Cooper JP
中科院分区：
文献类型：
--
作者：
Klutstein M;Cooper JP
有性生殖所特有的基因组混合需要亲本同源物重组的单倍体配子。为此，同源物必须在减数分裂期间配对。在一个拥挤的细胞核中，序列同源性被基因组的巨大规模和包装所掩盖，伴侣比对不是一项小任务。在这里，我们回顾一下这个过程的早期阶段。染色体首先建立一个最初的对接点，通常在端粒或着丝粒。染色体特异性结合因子模式的获得促进了同源物识别。然后，染色体被拴在核膜上，并进行核运动，“摆脱”不适当的接触，同时巩固同源物的关联。此后，通过建立联会复合体或其等价物并产生遗传交叉来稳定同源连接。将讨论这些阶段的作用的最新观点。
The intermingling of genomes that characterizes sexual reproduction requires haploid gametes in which parental homologs have recombined. For this, homologs must pair during meiosis. In a crowded nucleus where sequence homology is obscured by the enormous scale and packaging of the genome, partner alignment is no small task. Here we review the early stages of this process. Chromosomes first establish an initial docking site, usually at telomeres or centromeres. The acquisition of chromosome-specific patterns of binding factors facilitates homolog recognition. Chromosomes are then tethered to the nuclear envelope and subjected to nuclear movements that ‘shake off’ inappropriate contacts while consolidating homolog associations. Thereafter, homolog connections are stabilized by building the synaptonemal complex or its equivalent and creating genetic crossovers. Recent perspectives on the roles of these stages will be discussed.
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影响因子：
9.2
作者：
Funaya, Charlotta;Samarasinghe, Shivanthi;Pruggnaller, Sabine;Ohta, Midori;Connolly, Yvonne;Mueller, Jan;Murakami, Hiroshi;Grallert, Agnes;Yamamoto, Masayuki;Smith, Duncan;Antony, Claude;Tanaka, Kayoko
通讯作者：
Tanaka, Kayoko
影响因子：
64.5
作者：
Chikashige, Y;Tsutsumi, C;Hiraoka, Y
通讯作者：
Hiraoka, Y
影响因子：
56.9
作者：
CHIKASHIGE, Y;DING, DQ;HIRAOKA, Y
通讯作者：
HIRAOKA, Y
影响因子：
64.5
作者：
Conrad, Michael N.;Lee, Chih-Ying;Dresser, Michael E.
通讯作者：
Dresser, Michael E.
影响因子：
3.3
作者：
Davis, Luther;Smith, Gerald R.
通讯作者：
Smith, Gerald R.