The unique role of the frontal aslant tract in speech and language processing.
The unique role of the frontal aslant tract in speech and language processing.
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DOI：
10.1016/j.nicl.2022.103020
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发表时间：
2022
影响因子：
4.2
通讯作者：
Ivanova, Maria, V
中科院分区：
文献类型：
--
作者：
Zhong, Allison J.;Baldo, Juliana, V;Dronkers, Nina F.;Ivanova, Maria, V
额斜束损伤与言语失用症相关。即使考虑到附近的皮质区域，额斜束损伤也预示着言语失用症。额斜束的内侧段和外侧段可能代表正常的解剖变异。
额斜束是最近描述的一种连接额上回和额下回的脑叶内纤维束。额斜束与多种言语和语言过程及障碍有关，包括运动性言语障碍、口吃障碍、岛盖综合征和言语流畅性，但额斜束的具体功能尚未阐明。在当前的研究中，我们旨在通过研究额斜束在卒中后失语症患者言语和语言能力的运动方面所起的潜在作用来填补这一知识空白。我们有三个目标：1）利用一种强大的成像分析方法——高角分辨率扩散成像纤维束成像，确定额斜束损伤会影响哪些特定的运动性言语或语言能力；2）确定即使考虑到相邻皮质区域的皮质损伤，额斜束损伤是否与一系列运动性言语和语言任务的功能缺陷相关；3）探究额斜束的各个部分（外侧段和内侧段）在运动性言语表现中是否发挥不同的作用。我们假设与语言任务相比，额斜束损伤与运动性言语表现的相关性最强。我们分析了33名有慢性左半球卒中病史的失语症患者的高角分辨率扩散成像数据。额斜束指标与几项言语和语言测试的得分相关：运动性言语评估、西方失语症成套测验的失语商数和分项测试以及波士顿命名测试。我们的结果表明，正如预测的那样，额斜束的完整性与运动性言语评估密切相关，与西方失语症成套测验的分项测试得分（包括命名、理解和复述）呈弱负相关，这可能反映了这样一个事实，即这些西方失语症成套测验分项测试的表现与大脑后部区域的损伤相关，而额叶病变不太可能损伤这些区域。我们还进行了分层逐步回归，以根据额斜束的特性和周围皮质区域的病变负荷来预测语言功能。在考虑了额下回、腹侧中央前回和岛叶的上侧中央前回的作用后，额斜束仍然是运动性言语评估失用症得分的一个重要预测因子。我们的结果进一步表明，额斜束的内侧和外侧部分似乎没有发挥不同的作用，而可能表明额斜束的正常解剖变异。总体而言，目前的结果表明额斜束在运动性言语中发挥着特定而独特的作用。这些结果进一步加深了我们对白质纤维束在言语和语言中所起作用的理解。
Damage to the frontal aslant tract is associated with apraxia of speech. FAT damage predicts apraxia of speech even if accounting for nearby cortical areas. Medial and lateral segments of the FAT likely represent normal anatomic variations. The frontal aslant tract (FAT) is a recently described intralobar tract that connects the superior and inferior frontal gyri. The FAT has been implicated in various speech and language processes and disorders, including motor speech impairments, stuttering disorders, opercular syndrome, and verbal fluency, but the specific function(s) of the FAT have yet to be elucidated. In the current study, we aimed to address this knowledge gap by investigating the underlying role that the FAT plays in motor aspects of speech and language abilities in post-stroke aphasia. Our goals were three-fold: 1) To identify which specific motor speech or language abilities are impacted by FAT damage by utilizing a powerful imaging analysis method, High Angular Resolution Diffusion Imaging (HARDI) tractography; 2) To determine whether damage to the FAT is associated with functional deficits on a range of motor speech and language tasks even when accounting for cortical damage to adjacent cortical regions; and 3) To explore whether subsections of the FAT (lateral and medial segments) play distinct roles in motor speech performance. We hypothesized that damage to the FAT would be most strongly associated with motor speech performance in comparison to language tasks. We analyzed HARDI data from thirty-three people with aphasia (PWA) with a history of chronic left hemisphere stroke. FAT metrics were related to scores on several speech and language tests: the Motor Speech Evaluation (MSE), the Western Aphasia Battery (WAB) aphasia quotient and subtests, and the Boston Naming Test (BNT). Our results indicated that the integrity of the FAT was strongly associated with the MSE as predicted, and weakly negatively associated with WAB subtest scores including Naming, Comprehension, and Repetition, likely reflecting the fact that performance on these WAB subtests is associated with damage to posterior areas of the brain that are unlikely to be damaged with a frontal lesion. We also performed hierarchical stepwise regressions to predict language function based on FAT properties and lesion load to surrounding cortical areas. After accounting for the contributions of the inferior frontal gyrus, the ventral precentral gyrus, and the superior precentral gyrus of the insula, the FAT still remained a significant predictor of MSE apraxia scores. Our results further showed that the medial and lateral subsections of the FAT did not appear to play distinct roles but rather may indicate normal anatomical variations of the FAT. Overall, current results indicate that the FAT plays a specific and unique role in motor speech. These results further our understanding of the role that white matter tracts play in speech and language.
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影响因子：
2.9
作者：
Basilakos A;Fillmore PT;Rorden C;Guo D;Bonilha L;Fridriksson J
通讯作者：
Fridriksson J
DOI：
10.1016/j.cortex.2012.03.001
发表时间：
2013-03
期刊：
Cortex; a journal devoted to the study of the nervous system and behavior
影响因子：
--
作者：
Baldo JV;Arévalo A;Patterson JP;Dronkers NF
通讯作者：
Dronkers NF
影响因子：
16.2
作者：
Corbetta M;Ramsey L;Callejas A;Baldassarre A;Hacker CD;Siegel JS;Astafiev SV;Rengachary J;Zinn K;Lang CE;Connor LT;Fucetola R;Strube M;Carter AR;Shulman GL
通讯作者：
Shulman GL
影响因子：
2.5
作者：
Broce, Iris;Bernal, Byron;Dick, Anthony Steven
通讯作者：
Dick, Anthony Steven
影响因子：
3.4
作者：
Dronkers, NF;Wilkins, DP;Jaeger, JJ
通讯作者：
Jaeger, JJ