Alternative neural circuitry that might be impaired in the development of Alzheimer disease.
Alternative neural circuitry that might be impaired in the development of Alzheimer disease.
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DOI:
10.3389/fnins.2015.00145
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发表时间:
2015
影响因子:
4.3
通讯作者:
Hernandez F
中科院分区:
文献类型:
--
作者:
Avila J;Perry G;Strange BA;Hernandez F
It is well established that some individuals with normal cognitive capacity have abundant senile plaques in their brains. It has been proposed that those individuals are resilient or have compensation factors to prevent cognitive decline. In this comment, we explore an alternative mechanism through which cognitive capacity is maintained. This mechanism could involve the impairment of alternative neural circuitry. Also, the proportion of molecules such as Aβ or tau protein present in different areas of the brain could be important.
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DOI:
10.1073/pnas.0504136102
发表时间:
2005-07-05
影响因子:
11.1
作者:
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通讯作者:
Raichle, ME
DOI:
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2014
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NeuroImage. Clinical
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Maestú F
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2.5
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KOHLER, C
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Cercignani, Mara
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Klunk, William E.