Alternative neural circuitry that might be impaired in the development of Alzheimer disease.

Alternative neural circuitry that might be impaired in the development of Alzheimer disease.
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DOI:
10.3389/fnins.2015.00145
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发表时间:
2015
影响因子:
4.3
通讯作者:
Hernandez F
Hernandez F
中科院分区:
医学2区
文献类型:
--
作者:
Avila J;Perry G;Strange BA;Hernandez F

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一些认知能力正常的人的大脑中有大量的老年斑,这是公认的。有人提出,这些人有弹性或有补偿因素来防止认知能力下降。在这篇评论中,我们探索了认知能力维持的另一种机制。这种机制可能涉及到替代神经回路的损伤。此外,存在于大脑不同区域的Aβ或tau蛋白等分子的比例可能很重要。
It is well established that some individuals with normal cognitive capacity have abundant senile plaques in their brains. It has been proposed that those individuals are resilient or have compensation factors to prevent cognitive decline. In this comment, we explore an alternative mechanism through which cognitive capacity is maintained. This mechanism could involve the impairment of alternative neural circuitry. Also, the proportion of molecules such as Aβ or tau protein present in different areas of the brain could be important.
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