Patient-Specific Bioinks for 3D Bioprinting of Tissue Engineering Scaffolds.
Patient-Specific Bioinks for 3D Bioprinting of Tissue Engineering Scaffolds.
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DOI：
10.1002/adhm.201701347
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发表时间：
2018-06
影响因子：
10
通讯作者：
Tamayol A
中科院分区：
文献类型：
--
作者：
Faramarzi N;Yazdi IK;Nabavinia M;Gemma A;Fanelli A;Caizzone A;Ptaszek LM;Sinha I;Khademhosseini A;Ruskin JN;Tamayol A
生物打印已成为组织工程和再生医学领域有前途的工具。人们已经开发出各种三维（3D）打印策略来实现各种生物聚合物和水凝胶的生物打印。然而，生物因素的纳入尚未得到很好的探索。随着个性化医疗的重要性变得越来越明显，开发包含自体/患者特异性生物因子的生物墨水用于组织工程应用的需求变得更加明显。我们使用富含血小板的血浆 (PRP) 作为患者特异性的丰富自体生长因子来源，可以轻松地将其合并到水凝胶中并打印到 3D 结构中。 PRP 含有多种生长因子，可增强血管生成、干细胞募集和组织再生。在这里，我们报告了一种基于藻酸盐的生物墨水的开发，该生物墨水可以通过暴露于天然钙离子在植入时进行打印和交联。该平台可用于 PRP 相关生长因子的受控释放，最终可能增强血管形成和干细胞迁移。
Bioprinting has emerged as a promising tool in tissue engineering and regenerative medicine. Various three dimensional (3D) printing strategies have been developed to enable bioprinting of various biopolymers and hydrogels. However, the incorporation of biological factors has not been well explored. As the importance of personalized medicine is becoming more clear, the need for the development of bioinks containing autologous/patient-specific biological factors for tissue engineering applications becomes more evident. We used platelet-rich plasma (PRP) as a patient-specific rich source of autologous growth factors that can be easily incorporated to hydrogels and printed into 3D constructs. PRP contains a cocktail of growth factors enhancing angiogenesis, stem cell recruitment and tissue regeneration. Here, we report the development of an alginate-based bioink that can be printed and crosslinked upon implantation through exposure to native calcium ions. This platform can be used for the controlled release of PRP-associated growth factors which may ultimately enhance vascularization and stem cell migration.
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影响因子：
16
作者：
Bersini, Simone;Yazdi, Iman K.;Talo, Giuseppe;Shin, Su Ryon;Moretti, Matteo;Khademhosseini, Ali
通讯作者：
Khademhosseini, Ali
影响因子：
2.8
作者：
Lee, Vivian K.;Lanzi, Alison M.;Ngo, Haygan;Yoo, Seung-Schik;Vincent, Peter A.;Dai, Guohao
通讯作者：
Dai, Guohao
影响因子：
4.3
作者：
Bir, Shyamal Chandra;Esaki, Jiro;Sakata, Ryuzo
通讯作者：
Sakata, Ryuzo
影响因子：
6.6
作者：
Ferris, Cameron J.;Gilmore, Kerry J.;Panhuis, Marc In Het
通讯作者：
Panhuis, Marc In Het
影响因子：
14.8
作者：
Liang, Chun-Chi;Park, Ann Y.;Guan, Jun-Lin
通讯作者：
Guan, Jun-Lin