Efficacy of smoking cessation therapy alone or integrated with prolonged exposure therapy for smokers with PTSD: Study protocol for a randomized controlled trial.
Efficacy of smoking cessation therapy alone or integrated with prolonged exposure therapy for smokers with PTSD: Study protocol for a randomized controlled trial.
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单独戒烟治疗或与长期暴露治疗相结合对患有创伤后应激障碍 (PTSD) 的吸烟者的疗效：随机对照试验的研究方案。
DOI：
10.1016/j.cct.2016.08.012
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发表时间：
2016
影响因子：
2.2
通讯作者：
Rosenfield,David
中科院分区：
文献类型：
--
作者：
Powers,MarkB;Kauffman,BrookeY;Kleinsasser,AnneL;Lee-Furman,Eunjung;Smits,JasperAJ;Zvolensky,MichaelJ;Rosenfield,David
创伤后应激障碍(PTSD)与戒烟失败的风险增加有关。事实上，患有创伤后应激障碍的吸烟者的戒烟率(23.2%)是所有精神障碍中最低的之一。导致吸烟者发展为尼古丁依赖和戒烟复发的创伤后应激障碍的特征包括负面情绪、恐惧、觉醒增加、易怒、愤怒、痛苦不耐受和焦虑敏感。创伤后应激障碍患者的焦虑敏感度高于除惊恐障碍以外的任何其他焦虑症患者。高焦虑敏感度与戒烟过程中失误和复发的几率更大是唯一相关的。痛苦不耐受是一种不能容忍痛苦的感知或行为倾向，与创伤后应激障碍的维持和戒烟问题有关。长期暴露(PE)和内感暴露(IE)可减少创伤后应激障碍症状、痛苦不耐受和焦虑敏感性。因此，它们成为为创伤后应激障碍患者加强标准戒烟干预的有前途的候选者。本研究对患有创伤后应激障碍的吸烟者进行了为期12个疗程的专门治疗。这一综合创伤后应激障碍和吸烟治疗(IPST)结合了认知行为疗法和戒烟尼古丁替代疗法(标准护理；SC)，PE针对创伤后应激障碍症状，IE降低焦虑敏感性和痛苦不耐症。患有创伤后应激障碍的成年吸烟者(N=1080)将被随机分配到：(1)IPST或(2)SC。在0周、6周、8周、10周、14周、16周、22周和30周评估主要结果。
Posttraumatic stress disorder (PTSD) is related to an increased risk of smoking cessation failure. In fact, the quit rate in smokers with PTSD (23.2%) is one of the lowest of all mental disorders. Features of PTSD that contribute to smokers' progression to nicotine dependence and cessation relapse include negative affect, fear, increased arousal, irritability, anger, distress intolerance, and anxiety sensitivity. Anxiety sensitivity is higher in people with PTSD than in any other anxiety disorder except for panic disorder. High anxiety sensitivity is uniquely associated with greater odds of lapse and relapse during quit attempts. Distress intolerance, a perceived or behavioral tendency to not tolerate distress, is related to both the maintenance of PTSD and problems in quitting smoking. Prolonged exposure (PE) and interoceptive exposure (IE) reduce PTSD symptoms, distress intolerance, and anxiety sensitivity. Thus, they emerge as promising candidates to augment standard smoking cessation interventions for individuals with PTSD. The present study tests a 12-session specialized treatment for smokers with PTSD. This Integrated PTSD and Smoking Treatment (IPST) combines cognitive-behavioral therapy and nicotine replacement treatment for smoking cessation (standard care; SC) with PE to target PTSD symptoms and IE to reduce anxiety sensitivity and distress intolerance. Adult smokers (N= 80) with PTSD will be randomly assigned to either: (1) IPST or (2) SC. Primary outcomes are assessed at weeks 0, 6, 8, 10, 14, 16, 22, and 30.
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影响因子：
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DOI：
10.1016/s0005-7916(00)00012-4
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2000-06-01
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