Brain state limits propagation of neural signals in laminar cortical circuits.
Brain state limits propagation of neural signals in laminar cortical circuits.
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DOI：
10.1073/pnas.2104192119
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发表时间：
2022-07-26
影响因子：
11.1
通讯作者：
中科院分区：
文献类型：
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大脑的状态在一天中不断波动。这些波动是否以及如何影响大脑中的信号传播仍然未知。在这里，我们在不同的大脑状态下使用光遗传学刺激来表明神经元之间的耦合以状态依赖的方式调节信号在皮层回路中的传播。我们的研究结果表明，大脑状态会影响电信号在新皮层中的传播距离，并建议对依赖于神经网络中强大信号传播的计算模型进行修订。我们对环境的感知依赖于神经信号在皮层网络中的有效传播。在一天的时间过程中，神经反应会随着大脑状态的变化而剧烈波动，这可能会影响电信号在神经回路中的传播方式。尽管这个问题很重要，但尖峰活动的模式如何在不同大脑状态的神经元回路中传播仍然是未知的。在这里，我们使用多电极层状阵列来揭示大脑状态强烈地调节神经活动在早期视觉皮层（V1）层中的传播。我们光遗传学诱导了一组神经元内的同步状态转换，并研究了电信号在清醒和休息期间的传播距离。虽然光遗传学刺激在清醒期间相对于休息激发更强的神经反应，但信号在清醒期间仅微弱地传播穿过皮质柱，并且传播的程度与唤醒水平呈负相关。相反，光诱导的群体活动在休息期间在整个皮质柱中大力传播，即使当神经元在光刺激之前处于去激活的唤醒状态时。从机制上讲，整体大脑状态对层状回路中尖峰活动传播的影响可以通过神经元之间耦合的状态依赖性变化来解释。我们的研究结果施加约束的因果操纵研究的结论，试图影响神经功能和行为，以及在以前的计算模型的感知假设强大的信号传播皮层层和区域。
Brain state fluctuates throughout the course of the day. Whether and how these fluctuations impact signal propagation in the brain remains unknown. Here, we used optogenetic stimulation during different brain states to show that the coupling between neurons modulates the spread of signals across cortical circuits in a state-dependent manner. Our results indicate that brain state influences how far electrical signals travel in neocortex and suggest a revision of computational models relying on robust signal propagation across neural networks. Our perception of the environment relies on the efficient propagation of neural signals across cortical networks. During the time course of a day, neural responses fluctuate dramatically as the state of the brain changes to possibly influence how electrical signals propagate across neural circuits. Despite the importance of this issue, how patterns of spiking activity propagate within neuronal circuits in different brain states remains unknown. Here, we used multielectrode laminar arrays to reveal that brain state strongly modulates the propagation of neural activity across the layers of early visual cortex (V1). We optogenetically induced synchronized state transitions within a group of neurons and examined how far electrical signals travel during wakefulness and rest. Although optogenetic stimulation elicits stronger neural responses during wakefulness relative to rest, signals propagate only weakly across the cortical column during wakefulness, and the extent of spread is inversely related to arousal level. In contrast, the light-induced population activity vigorously propagates throughout the entire cortical column during rest, even when neurons are in a desynchronized wake-like state prior to light stimulation. Mechanistically, the influence of global brain state on the propagation of spiking activity across laminar circuits can be explained by state-dependent changes in the coupling between neurons. Our results impose constraints on the conclusions of causal manipulation studies attempting to influence neural function and behavior, as well as on previous computational models of perception assuming robust signal propagation across cortical layers and areas.
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