Low serum 25-hydroxyvitamin D3 levels and late delayed radiation-induced brain injury in patients with nasopharyngeal carcinoma: A case-control study.
Low serum 25-hydroxyvitamin D3 levels and late delayed radiation-induced brain injury in patients with nasopharyngeal carcinoma: A case-control study.
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DOI：
10.1002/brb3.1892
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发表时间：
2020-12
影响因子：
3.1
通讯作者：
Huang H
中科院分区：
文献类型：
--
作者：
Deng Z;Li M;Guo J;Zhou D;Huang X;Huang Y;Huang H
炎症反应在迟发性辐射脑损伤（RBI）的发病机制中起关键作用。低维生素D水平与多种免疫炎性疾病密切相关，但与晚发性RBI的关系尚不清楚。在这里，我们的目的是确定鼻咽癌晚期延迟性RBI患者血清维生素D水平与临床参数的关系。对21例RBI患者的25‐羟维生素D3水平、临床和脑脊液参数进行了评估，并与90例年龄、性别和季节匹配的健康对照进行了比较。RBI患者的25‐（OH）D3水平低于对照组（40.39±22.11 vs. 64.54±19.89 nmol/L, p < 0.001），尤其是年龄≥60岁（vs. <60岁，p = 0.038）、女性（vs.男性，p = 0.012）、短潜伏期（<5年）（vs.≥5年，p = 0.015）和严重损害（LENT/SOMA评分≥3）（vs. LENT/SOMA评分<3,p = 0.010）。血清25‐（OH）D3水平与年龄相关（r =−）。464, p = .015),延迟的央行(r = .416, p = .031)和借给/ SOMA (r =−规模。488, p = 0.010)。我们的数据显示，鼻咽癌晚期延迟性RBI患者血清25‐（OH）D3水平降低。炎症反应在RBI的发病机制中起关键作用。低维生素D水平与多种免疫炎性疾病密切相关，但与晚发性RBI的关系尚不清楚。在这里，我们报道了RBI患者的血清25(OH)D3水平明显低于年龄、季节和性别匹配的对照组。此外，低水平的25(OH)D3与女性、年龄较大、潜伏期短和疾病残疾有关。
Inflammatory reaction plays a critical role in the pathogenesis of late delayed radiation‐induced brain injury (RBI). Low vitamin D levels are closely associated with various immuno‐inflammatory diseases, but the relationship with late delayed RBI remains unknown. Here, we aimed to determine the association of serum vitamin D levels with clinical parameters in late delayed RBI patients with nasopharyngeal carcinoma. 25‐Hydroxyvitamin D3 levels and clinical and cerebrospinal fluid parameters were evaluated in 21 patients with RBI and compared with 90 age‐, sex‐, and season‐matched healthy controls. 25‐(OH)D3 levels were lower in patients with RBI compared to controls (40.39 ± 22.11 vs. 64.54 ± 19.89 nmol/L, p < .001), especially for aged ≥60 years (vs. <60 years, p = .038), females (vs. males, p = .012), short latency (<5 years) (vs. ≥5 years, p = .015), and severe impairment (LENT/SOMA score ≥3) (vs. LENT/SOMA score <3, p = .010). Serum 25‐(OH)D3 levels were associated with age (r = −.464, p = .015), Latency of RBI (r = .416, p = .031) and LENT/SOMA Scale (r = −.488, p = .010). Our data showed that serum 25‐(OH)D3 levels were reduced in late delayed RBI patients with nasopharyngeal carcinoma. Inflammatory reaction plays a critical role in the pathogenesis of RBI. Low vitamin D levels are closely associated with various immuno‐inflammatory diseases, but the relationship with late delayed RBI remains unknown. Here, we reported that patients with RBI had significantly lower serum levels of 25(OH)D3 than age‐, season‐ and sex‐matched control subjects. Furthermore, low levels of 25(OH)D3 were associated with female sex, older age, short latency, and disease disability.
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影响因子：
7.3
作者：
Weissert R
通讯作者：
Weissert R
DOI：
10.1016/j.ijrobp.2015.02.011
发表时间：
2015-07-01
影响因子：
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作者：
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影响因子：
5.6
作者：
Balentova S;Adamkov M
通讯作者：
Adamkov M
DOI：
10.1016/s0360-3016(02)04578-9
发表时间：
2003-06-01
影响因子：
7
作者：
Routledge, JA;Burns, MP;Davidson, SE
通讯作者：
Davidson, SE