A trigeminal conditioned stimulus yields fast acquisition of cerebellum-dependent conditioned eyeblinks.
A trigeminal conditioned stimulus yields fast acquisition of cerebellum-dependent conditioned eyeblinks.
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DOI：
10.1016/j.bbr.2011.09.010
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发表时间：
2012-01-01
影响因子：
2.7
通讯作者：
Bracha, Vlastislav
中科院分区：
文献类型：
--
作者：
Carrel, Andrew J.;Zbarska, Svitlana;Zenitsky, Gary D.;Bracha, Vlastislav
经典条件反射的眨眼反应在兔子是一种形式的运动学习，其中动物学习，以回应最初无关的条件刺激（CS）。人们认为获得性条件反应（CR）是适应性的，因为它们在预期潜在有害事件时保护眼睛。这种保护机制令人惊讶地效率低下，因为获得CR需要大量的训练-这种情况在自然界中不太可能发生。我们假设兔子的条件反射率可能取决于CS模式，并且刺激作为CS的触须肌可以比传统的听觉或视觉刺激更快地产生CR采集。我们测试了这一假设，条件天真的兔子在延迟范例中使用弱喷气CS（vCS）直接对同侧的眼肌触须。我们发现，三叉神经vCS产生显着更快的CR采集。我们接下来检查vCS诱发的CR是否与传统听觉CS诱发的CR以相同的方式依赖于中间小脑。我们发现，触须CRs可以取消与蝇蕈醇灭活小脑间置核（IN）。此外，在IN中注射印防己毒素缩短了触须CR的起始潜伏期。这些发现表明，音调和vCS诱发的CR共享类似的小脑依赖性。
Classical conditioning of the eyeblink response in the rabbit is a form of motor learning whereby the animal learns to respond to an initially irrelevant conditioned stimulus (CS). It is thought that acquired conditioned responses (CRs) are adaptive because they protect the eye in anticipation of potentially harmful events. This protective mechanism is surprisingly inefficient because the acquisition of CRs requires extensive training – a condition which is unlikely to occur in nature. We hypothesized that the rate of conditioning in rabbits could depend on CS modality and that stimulating mystacial vibrissae as the CS could produce CR acquisition faster than the traditional auditory or visual stimulation. We tested this hypothesis by conditioning naïve rabbits in the delay paradigm using a weak air-puff CS (vCS) directed to the ipsilateral mystacial vibrissae. We found that the trigeminal vCS yields significantly faster CR acquisition. We next examined if vCS-evoked CRs are dependent on the intermediate cerebellum in the same fashion as CRs evoked by the traditional auditory CS. We found that vibrissal CRs could be abolished by inactivating the cerebellar interposed nuclei (IN) with muscimol. In addition, injections of picrotoxin in the IN shortened the onset latency of vibrissal CRs. These findings suggest that the tone and vCS-evoked CRs share similar cerebellar dependency.
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影响因子：
1.9
作者：
Christian, KM;Thompson, RF
通讯作者：
Thompson, RF
影响因子：
2.9
作者：
Chen, GX;Steinmetz, JE
通讯作者：
Steinmetz, JE
DOI：
10.3758/bf03213365
发表时间：
1985-01-01
期刊：
ANIMAL LEARNING & BEHAVIOR
影响因子：
--
作者：
HOLT, PE;KEHOE, EJ
通讯作者：
KEHOE, EJ
影响因子：
3.5
作者：
Jirenhed, Dan-Anders;Hesslow, Germund
通讯作者：
Hesslow, Germund
影响因子：
2.9
作者：
Bracha, V;Irwin, KB;Bloedel, JR
通讯作者：
Bloedel, JR